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GCRF_NF437 High Performance Low Cost Ventilator (HPLV) project Cost Ventilator (HPLV) project

GCRF_NF437 高性能低成本呼吸机 (HPLV) 项目成本呼吸机 (HPLV) 项目

基本信息

批准号：
EP/V043129/1
负责人：
Ian Lazarus
金额：
$ 97.85万
依托单位：
Science and Technology Facilities Council
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FV043129%2F1
关键词：
GCRF_NF437 Performance Low Cost Ventilator

项目摘要

The unmet need addressed by the High Performance Low-cost Ventilator (HPLV) project is the shortage of ventilators for patient care in OECD DAC list countries. The global pandemic of COVID-19 has highlighted this lack of ventilators which is in-turn compounded by a shortage of trained staff available to operate them. Beyond COVID-19, there remain the critical requirements of caring for pneumonia patients and others suffering from acute respiratory conditions in the OECD DAC-list countries.This project takes as its starting point the HEV (High Energy physics Ventilator) developed by the CERN particle physics laboratory in Geneva with advice and guidance from WHO with the aim of being suitable for OECD DAC list use. HEV has been developed using techniques routinely used in the context of CERN research, including for delivery and regulation of gases, and for sophisticated monitoring and control. Nevertheless, HEV was designed to be reasonably priced, robust, easily maintained and able to operate in an environment where oxygen supply pressure is variable, power is unreliable and few trained staff are available. The result is a resilient and simple design with comprehensive in-built options for remote training, monitoring, and operation, which does not compromise on either performance or functionality, but allows easy operation via a multi-lingual user interface.Within this HPLV project, partners in Brazil will identify local difficulties encountered when ventilating patients and input that information to the design team working on re-engineering the HEV ventilator into an HPLV design. Regulatory experts in the UK will also provide valuable guidance on this re-engineering activity. As well as re-engineering an HPLV prototype in line with real-world advice from Brazil, the HPLV project team will provide the necessary documentation to accompany the HPLV design, such that it is ready for regulatory approval. This is a key milestone to enabling commercial organisations to bridge the gap between prototyping and manufacture for use in a medical environment.The end point of this project will be reached when the new re-engineered HPLV prototype has been successfully tested in Brazil and the technical file is available for companies to use when they license the design for manufacture and sale to OECD DAC list users.

高性能低成本呼吸机（HPLV）项目解决的未满足需求是经合组织DAC名单国家患者护理呼吸机短缺。COVID-19的全球大流行凸显了呼吸机的短缺，而训练有素的操作人员的短缺又加剧了这种短缺。除2019冠状病毒病外，在经合组织dac名单国家中，仍然存在照顾肺炎患者和其他急性呼吸道疾病患者的关键需求。本项目以日内瓦CERN粒子物理实验室在世卫组织的建议和指导下开发的HEV（高能物理通风机）为起点，目的是适合经合组织DAC清单的使用。混合动力汽车是利用欧洲核子研究中心研究中经常使用的技术开发的，包括用于输送和调节气体，以及用于复杂的监测和控制。然而，HEV的设计是价格合理、坚固耐用、易于维护，并且能够在氧气供应压力变化、电力不可靠和训练有素的工作人员很少的环境中运行。其结果是具有弹性和简单的设计，具有全面的内置远程培训，监控和操作选项，这不会损害性能或功能，但允许通过多语言用户界面轻松操作。在这个HPLV项目中，巴西的合作伙伴将确定患者呼吸时遇到的当地困难，并将这些信息输入设计团队，以便将HEV呼吸机重新设计为HPLV设计。英国的监管专家也将为这一重组活动提供宝贵的指导。除了根据巴西的实际建议重新设计HPLV原型外，HPLV项目团队还将提供伴随HPLV设计的必要文件，以便为监管部门的批准做好准备。这是一个关键的里程碑，使商业组织能够弥合原型设计和用于医疗环境的制造之间的差距。当新的重新设计的HPLV原型在巴西成功测试，技术文件可供公司使用时，该项目将达到终点，当他们将设计许可用于制造和销售给经合组织DAC列表用户时。