GCRF_NF437 High Performance Low Cost Ventilator (HPLV) project Cost Ventilator (HPLV) project

高性能低成本呼吸机（HPLV）项目解决的未满足需求是OECD DAC名单国家患者护理呼吸机短缺。COVID-19全球大流行凸显了这种缺乏消毒机的情况，而这反过来又因缺乏训练有素的员工来操作消毒机而加剧。除了COVID-19，在OECD DAC名单国家，仍有肺炎患者和其他急性呼吸系统疾病患者的护理需求。该项目以位于日内瓦的CERN粒子物理实验室在世卫组织的建议和指导下开发的HEV（高能物理呼吸机）为起点，旨在适用于OECD DAC名单。HEV是使用CERN研究中常规使用的技术开发的，包括气体的输送和调节，以及复杂的监测和控制。尽管如此，混合动力汽车的设计价格合理，坚固耐用，易于维护，能够在氧气供应压力可变，电力不可靠和训练有素的工作人员很少的环境中运行。其结果是一个弹性和简单的设计，具有全面的内置选项，用于远程培训，监控和操作，这不会影响性能或功能，但允许通过多语言用户界面轻松操作。在这个HPLV项目中，巴西的合作伙伴将确定在为患者通气时遇到的当地困难，并将这些信息输入到设计团队，将HEV通风机设计成HPLV设计。英国的监管专家也将为这项重新设计活动提供宝贵的指导。除了根据巴西的实际建议重新设计HPLV原型外，HPLV项目团队还将提供必要的文件来支持HPLV设计，以便为监管部门的批准做好准备。这是一个重要的里程碑，使商业组织能够弥合原型设计和制造之间的差距差距，用于医疗环境。当新的重新设计的HPLV原型在巴西成功测试时，该项目将达到终点，技术文件可供公司使用，当他们许可设计制造和销售给经合组织DAC列表用户时。

The unmet need addressed by the High Performance Low-cost Ventilator (HPLV) project is the shortage of ventilators for patient care in OECD DAC list countries. The global pandemic of COVID-19 has highlighted this lack of ventilators which is in-turn compounded by a shortage of trained staff available to operate them. Beyond COVID-19, there remain the critical requirements of caring for pneumonia patients and others suffering from acute respiratory conditions in the OECD DAC-list countries.This project takes as its starting point the HEV (High Energy physics Ventilator) developed by the CERN particle physics laboratory in Geneva with advice and guidance from WHO with the aim of being suitable for OECD DAC list use. HEV has been developed using techniques routinely used in the context of CERN research, including for delivery and regulation of gases, and for sophisticated monitoring and control. Nevertheless, HEV was designed to be reasonably priced, robust, easily maintained and able to operate in an environment where oxygen supply pressure is variable, power is unreliable and few trained staff are available. The result is a resilient and simple design with comprehensive in-built options for remote training, monitoring, and operation, which does not compromise on either performance or functionality, but allows easy operation via a multi-lingual user interface.Within this HPLV project, partners in Brazil will identify local difficulties encountered when ventilating patients and input that information to the design team working on re-engineering the HEV ventilator into an HPLV design. Regulatory experts in the UK will also provide valuable guidance on this re-engineering activity. As well as re-engineering an HPLV prototype in line with real-world advice from Brazil, the HPLV project team will provide the necessary documentation to accompany the HPLV design, such that it is ready for regulatory approval. This is a key milestone to enabling commercial organisations to bridge the gap between prototyping and manufacture for use in a medical environment.The end point of this project will be reached when the new re-engineered HPLV prototype has been successfully tested in Brazil and the technical file is available for companies to use when they license the design for manufacture and sale to OECD DAC list users.