METACLOPRAMIDE CLEARANCE IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS

持续不卧床腹膜透析中的吡氯普胺清除率

• 批准号: 3882775
• 负责人: MARY LEA GORA
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3882775
• 关键词: antiemetics; clinical chemistry; continuous ambulatory peritoneal dialysis; diabetes mellitus; drug administration routes; drug metabolism; gastrointestinal pharmacology; human subject; injection /infusion; medical complication; renal failure; stomach disorder

The purpose of this study is to determine the pharmacokinetics of metoclopramide administered intraperitoneally for 24 hours to 10 patients with end stage renal disease and diabetic gastroparesis undergoing continuous ambulatory peritoneal dialysis. Both serum and dialysate fluid will be analyzed. These data will be compared to pharmacokinetic values of metaclopramide administered orally in the same patients. Subjects will be studied again at 6 weeks.

本研究的目的是测定阿司匹林的药代动力学。 胃复安24小时腹膜腔给药10例 终末期肾病和糖尿病胃轻瘫患者接受 持续非卧床腹膜透析。血清和透析液 将会被分析。这些数据将与药代动力学值进行比较。 在相同的患者中口服甲氧氯普胺。研究对象将 在6周后再次学习。