Contribution of bone marrow-derived cells to renal fibrosis and elucidation of cell signalling mechanisms

骨髓源性细胞对肾纤维化的贡献及细胞信号传导机制的阐明

• 批准号: nhmrc : 436770
• 负责人: A/Pr Jinhua Li
• 金额: $ 28.52万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contribution-bone-marrow-signalling-mechanisms/100523
• 关键词: Contribution; bone; marrow; derived; cells

This study investigates the contribution of bone marrow-derived adult stem cells to the development of renal scarring, an important process proceeding to end-stage renal disease (ESRD). There is increasing evidence demonstrating that bone marrow (BM)-derived cells can transform into renal cells and participate in the repair of damaged renal blood vessels. Our recent study demonstrated BM-derived stem cells can also transform to renal myofibroblasts, the major cell type that contributes to the development of kidney scarring. This suggests that BM-derived adult stem cells have dual roles: to repair or worsen the development of renal scarring. The present study investigates this adult stem cell's transformation and explores the potential measures to enhance the benefits and to block the harmful roles from these adult stem cells. The importance of BM-derived stem cells in the repair of damaged kidney will be determined and thus will provide preliminary insights into the future utilization of BM-derived stem cells in the treatment of chronic renal disease. Understanding the dual roles of BM-derived stem cells in experimental renal scarring, will lead us to question our current thinking and approaches to the treatment and management of renal fibrosis, and perhaps fibrosis in other organs. Evidence of two opposite roles which BM-derived adult stem cells play in the process of renal scarring may be helpful not only for the design of novel therapies to prevent or retard the progression of renal fibrosis, but also for manipulating adult stem cells for the treatment of renal disease.

本研究探讨了骨髓来源的成体干细胞对肾瘢痕形成的作用，肾瘢痕形成是终末期肾病（ESRD）的一个重要过程。越来越多的证据表明，骨髓（BM）来源的细胞可以转化为肾细胞，并参与修复受损的肾血管。我们最近的研究表明，BM来源的干细胞也可以转化为肾肌成纤维细胞，这是导致肾瘢痕形成的主要细胞类型。这表明BM衍生的成体干细胞具有双重作用：修复或恶化肾瘢痕的发展。本研究探讨了这种成体干细胞的转化，并探讨了增强这些成体干细胞的益处和阻断其有害作用的潜在措施。BM衍生的干细胞在受损肾脏修复中的重要性将被确定，从而将为BM衍生的干细胞在慢性肾脏疾病治疗中的未来利用提供初步见解。了解骨髓源性干细胞在实验性肾瘢痕形成中的双重作用，将使我们质疑我们目前治疗和管理肾纤维化的思想和方法，也许还有其他器官的纤维化。骨髓来源的成体干细胞在肾瘢痕形成过程中发挥两种相反作用的证据不仅有助于设计新的治疗方法来预防或延缓肾纤维化的进展，而且有助于操纵成体干细胞治疗肾脏疾病。