New insights into the role of renal endothelial dysfunction in the pathogenesis of glomerular injury and renal fibrosis

肾内皮功能障碍在肾小球损伤和肾纤维化发病机制中的作用的新见解

• 批准号: nhmrc : 606540
• 负责人: A/Pr Jinhua Li
• 金额: $ 38.52万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-insights-role-renal-fibrosis/96747
• 关键词: New; insights; into; role; renal

This project will ascertain whether abnormal function of endothelial cells contribute to diabetic and non-diabetic kidney diseases, the leading cause of end-stage kidney disease. The outcome of this study will allow us to reevaluate the role of endothelial cells in kidney scarring, lead us to question our current approaches to the treatment and management of chronic kidney disease and eventually may be helpful for the design of novel therapies to treat chronic kidney diseases.

该项目将确定内皮细胞功能异常是否会导致糖尿病和非糖尿病肾病，这是终末期肾病的主要原因。这项研究的结果将使我们能够重新评估内皮细胞在肾脏疤痕形成中的作用，使我们质疑目前治疗和管理慢性肾脏疾病的方法，并最终可能有助于设计治疗慢性肾脏疾病的新疗法。