Contribution of MDSC-derived cysteine cathepsins in breast cancer metastasis to bone

MDSC 衍生的半胱氨酸组织蛋白酶在乳腺癌骨转移中的作用

• 批准号: nhmrc : GNT1091636
• 负责人: Dr Laura Edgington-Mitchell
• 金额: $ 30.94万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/contribution-mdsc-derived-metastasis-bone/1345848
• 关键词: Contribution; MDSC; derived; cysteine; cathepsins

Cathepsins are enzymes called proteases that function to cleave specific proteins, a process that is important for many normal cellular functions. Aberrant cathepsin activity can result in a number of pathologies, including cancer and inflammation. We are developing tools called activity-based probes to study the function of cathepsins in disease. Specifically, we will investigate their activity within cells of the immune system with the goal of developing novel therapeutic approaches.

组织蛋白酶是一种被称为蛋白酶的酶，其功能是切割特定的蛋白质，这一过程对许多正常的细胞功能很重要。异常的组织蛋白酶活性可导致许多病理，包括癌症和炎症。我们正在开发称为基于活性的探针的工具，以研究组织蛋白酶在疾病中的功能。具体来说，我们将研究它们在免疫系统细胞内的活性，目的是开发新的治疗方法。