Novel chemical tools to study cathepsin X activation

研究组织蛋白酶 X 激活的新型化学工具

• 批准号: DE180100418
• 负责人: Dr Laura Edgington-Mitchell
• 金额: $ 29.33万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-12-05 至 2023-04-05
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE180100418
• 关键词: Novel; chemical; tools; study; cathepsin

This project aims to develop new chemical tools that can measure the specific activation of cathepsin X in cells, tissues, and live animals, as well as specific inhibitors for cathepsin X. The cysteine protease cathepsin X mediates basic biological functions that are essential for life, including cell communication, phagocytosis, immune maturation and neuritogenesis. The outcomes should benefit the wider research community. They could have long-term implications for health and disease, and deliver economic benefits through commercialisation of the novel tools.

该项目旨在开发新的化学工具，可以测量组织蛋白酶X在细胞、组织和活体动物中的特异性激活，以及组织蛋白酶X的特异性抑制剂。半胱氨酸蛋白酶组织蛋白酶X介导生命所必需的基本生物学功能，包括细胞通讯、吞噬、免疫成熟和神经生成。研究结果应该有利于更广泛的研究界。它们可能对健康和疾病产生长期影响，并通过新工具的商业化带来经济效益。