IN VITRO EVALUATION/CHEMICAL CANDIDATES IN VIVO TESTING

体外评估/候选化学物质体内测试

• 批准号: 3626299
• 负责人: RICHARD SAN
• 金额: $ 31.09万
• 依托单位: MICROBIOLOGICAL ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-26 至 1994-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3626299
• 关键词: bioassay; carcinogen testing; chemical carcinogen; laboratory mouse; mutagen testing

The Office of the Director, Division of Cancer Etiology, for many years, has had a contract to perform mutagenicity assays (Mouse Lymphoma L5178Y TK+/-) in support of extramural and intramural activities of the Division, with particular emphasis on providing in vitro data for use in the NCI chemical selection process of chemicals nominated, for carcinogenicity testing, to the National Toxicology Program. Since there is often a paucity of in vitro data on chemicals under consideration, the information obtained from these assays is most important in permitting the members of the Chemical Selection Working Group (CSWG) to make informed decisions in a timely fashion. The objective of this procurement is to perform Mouse Lymphoma L5178Y TK+/- assays and report on between 20-30 compounds per year, with about one third of the compounds requiring an additional assay before the final report is written.

主任办公室，癌症病因学部门，多年来，