IN VITRO EVALUATION/CHEMICAL CANDIDATES IN VIVO TESTING

体外评估/候选化学物质体内测试

• 批准号: 3626303
• 负责人: RICHARD SAN
• 金额: $ 34.12万
• 依托单位: MICROBIOLOGICAL ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-26 至 1994-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3626303
• 关键词: bioassay; carcinogen testing; chemical carcinogen; laboratory mouse; mutagen testing

The Office of the Director, Division of Cancer Etiology, for many years, has had a contract to perform mutagenicity assays (Mouse Lymphoma L5178Y TK+/-) in support of extramural and intramural activities of the Division, with particular emphasis on providing in vitro data for use in the NCI chemical selection process of chemicals nominated, for carcinogenicity testing, to the National Toxicology Program. Since there is often a paucity of in vitro data on chemicals under consideration, the information obtained from these assays is most important in permitting the members of the Chemical Selection Working Group (CSWG) to make informed decisions in a timely fashion. The objective of this procurement is to perform Mouse Lymphoma L5178Y TK+/- assays and report on between 20-30 compounds per year, with about one third of the compounds requiring an additional assay before the final report is written.

多年来，癌症病因学部主任办公室， 已签订合同进行致突变性试验（小鼠淋巴瘤L5178 Y 支持该司的校外和校内活动， 特别强调提供用于NCI的体外数据 提名化学品致癌性的化学品选择程序 国家毒理学计划 由于经常有一个 缺乏关于所审议化学品的体外数据， 从这些测定中获得的是最重要的， 化学品选择工作组（CSWG）做出知情决定， 及时的时尚。 本次采购的目的是执行鼠标 Lymphoma L5178 Y TK+/-检测并报告20-30种化合物， 大约三分之一的化合物需要额外的检测 在最终报告写出来之前。