A Soft Endorobot (SoftEn) for autonomous colonoscopy screening and treatment

用于自主结肠镜检查和治疗的软腔机器人 (SoftEn)

• 批准号: EP/W00433X/1
• 负责人: Luigi Manfredi
• 金额: $ 38.59万
• 依托单位: University of Dundee
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FW00433X%2F1
• 关键词: Soft; Endorobot; SoftEn; autonomous; colonoscopy

Colorectal cancer (CRC) is the third cause of cancer death worldwide. In 2018, about 1.8 million new cases were reported worldwide with a mortality of almost 900,000. This has increased more than 30% since 2012. Studies have shown that regular screening and early detection can reduce mortality by up to 70%. The proposed project will undertake interdisciplinary research to design a low-cost, disposable, autonomous Soft Endorobot (SoftEn) to examine the lower intestine painlessly. SoftEn offers disruptive potential to replace the current optical colonoscopy (OC), including a dual capability of investigation and performance of autonomous surgical tasks. SoftEn will overcome OC's limitations (operator-dependent, patient pain/discomfort, high costs, decontamination). Crucially, the high level of autonomy will reduce the time in performing the procedure as well as shift screening process from secondary to intermediate or primary care, thus saving precious time for diagnosis and intervention.Advantages of this approach are:1. Efficiency of the procedure will be augmented by reducing the human-operator skills required to perform the procedure. This will increase the number of procedures performed every year.2. Reducing the waiting list will consequently improve the CRC stage of detection and will increase the patient survivability due to early intervention and reduced cost of treatment.3. Less pain and discomfort will increase the patient acceptability of the screening as well as patient experience. This has the potential to make sedation unnecessary, which in turn would make hospital visits shorter.4. Autonomous robot examination of the large intestine would remove restrictions of the traditional operator-dependent OC and would enable an increased access to investigation. Optical diagnosis and tissue diagnosis could be achieved in most of the procedures, including patients requiring more advanced intervention.5. Potentially improve screening uptake through reducing barriers to participation.6. The use of polymers implies a reduction in production costs, allowing the device to be single-use and avoiding additional costs required for a traditional OC, including sterilisation and reprocessing. This will reduce the UK cost in CRC procedures.7. AI software will allow the endorobot to perform procedures autonomously. A clinician can therefore supervise several devices and intervene only if needed via an external ergonomic control console, locally or remotely. This will limit the use of clinicians' time and increase the number of investigations performed per day. Additionally, more clinicians will be able to perform the procedure supporting the national endoscopy workflow.

结直肠癌(CRC)是全球第三大癌症死亡原因。2018年，全球新增病例约180万例，死亡人数近90万人。自2012年以来，这一数字增长了30%以上。研究表明，定期筛查和早期发现可以将死亡率降低高达70%。拟议的项目将进行跨学科研究，以设计一种低成本、一次性、自主的Soft Endorobot(Soft Endorobot)，以无痛地检查下肠道。Soften提供了颠覆性的潜力来取代目前的光学结肠镜检查(OC)，包括调查和执行自主手术任务的双重能力。Soften将克服OC的局限性(依赖于操作员、患者痛苦/不适、高成本、去污)。重要的是，高度的自主性将减少实施该程序的时间，并将筛查过程从二级转移到中级或初级护理，从而节省宝贵的诊断和干预时间。这种方法的优点是：1.通过减少执行该程序所需的操作员技能，将提高该程序的效率。这将增加每年进行的手术次数。因此，减少等待名单将改善结直肠癌的检测阶段，并将由于早期干预和降低治疗成本而增加患者的存活率。减少疼痛和不适将增加患者对筛查的接受度和患者体验。这有可能使镇静剂变得不必要，这反过来又会缩短就诊时间。机器人对大肠的自主检查将消除传统依赖操作员的OC的限制，并将使更多的人能够进行调查。光学诊断和组织诊断在大多数手术中都可以实现，包括需要更先进的介入治疗的患者。通过减少参与的障碍，潜在地提高筛查的接受度。聚合物的使用意味着生产成本的降低，使设备可以一次性使用，并避免了传统OC所需的额外成本，包括灭菌和再加工。这将降低英国在CRC程序上的成本。人工智能软件将允许内机器人自主执行程序。因此，临床医生可以监控多个设备，并仅在需要时通过外部人体工程学控制台进行干预，无论是本地还是远程。这将限制临床医生的时间使用，并增加每天进行的调查数量。此外，更多的临床医生将能够执行支持国家内窥镜工作流程的程序。

项目成果

Imaging Systems for GI Endoscopy, and Graphs in Biomedical Image Analysis - First MICCAI Workshop, ISGIE 2022, and Fourth MICCAI Workshop, GRAIL 2022, Held in Conjunction with MICCAI 2022, Singapore, September 18, 2022, Proceedings

用于胃肠道内窥镜检查的成像系统和生物医学图像分析中的图形 - 第一届 MICCAI 研讨会，ISGIE 2022，和第四届 MICCAI 研讨会，GRAIL 2022，与 MICCAI 2022 联合举行，新加坡，2022 年 9 月 18 日，会议记录

• DOI: 10.1007/978-3-031-21083-9_4
• 发表时间: 2022
• 作者: Al-Bander B