Ultra-Liquid-Repellent Surfaces: from wetting to anti-biofouling properties
超防液表面:从润湿性能到抗生物污损性能
基本信息
- 批准号:EP/W010852/1
- 负责人:
- 金额:$ 40.03万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2022
- 资助国家:英国
- 起止时间:2022 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Significant incidence of hospital-acquired infections due to fouling of biomedical devices, which are major public health threats contributing to prolonged hospital stay and death, has generated much attention over the past two decades. For example, indwelling urinary catheters are responsible for most hospital-acquired urinary tract infections (UTIs), which account for approximately 35-40% of all hospital-acquired infections. This is followed by surgical site infections that account for 20% of all hospital-acquired infections. The pathogenesis of these infections is related to the susceptibility of device/instrument surfaces to bacterial adhesion and microbial colonization. Under these circumstances, invasion of the bacteria to human bodies via medical devices such as surgical instruments and catheters (e.g., migrating along the urinary tract to the bladder and kidneys) is made utterly easy by the spreading and adhesion of liquids such as contaminated urine, blood and even water/moisture. However, due to insufficient attention to and understanding of wetting and adhesion of complex physiological fluids on the surfaces (both external and internal) of biomedical devices, there has been rather limited progress in preventing fouling-associated infections.This proposal aims to gain an in-depth understanding of wetting and adhesion for anti-biofouling surfaces relevant for biomedical devices. 'Wetting' refers to how a liquid deposited on a surface spreads out. The phenomena of wetting are governed by interfacial tension and surface structure. In the case of droplets of liquid on a non-wettable surface, the droplets can form a roughly spherical shape, exhibiting a contact angle approaching 180 degrees. This allows droplets that are in contact with a liquid repellent surface to slide/roll off easily and remove surface contamination. By contrast, droplets will spread spontaneously on fully wettable solid surfaces to form a thin film. Recent advances in wetting-based applications have demonstrated that surfaces with extreme liquid repellence have great potential to facilitate anti-biofouling properties. Design and application of surfaces with improved durability and anti-biofouling properties whereby wetting and adhesion behaviours can be manipulated will be demonstrated in this work. Firstly, we will use state-of-the-art fabrication techniques to prepare various liquid repellent surfaces. This will allow us to compare and optimise the liquid repellence of the fabricated surface patterns, and thereby, prevent the impalement of the liquid into the fabricated surface structure in order to avoid contamination and corrosion. Specifically, we will investigate the wetting and adhesion behaviours of complex liquids, including urine and blood, to facilitate the development of ultra-liquid-repellent surfaces. We will develop methods to test how the surface properties are affected by interactions with various liquids. Where applicable, we will assess the impact of surface defects before and after interactions with the contaminating liquids. This is to improve the inherent antifouling properties by reducing surface-associated biofilm growth resulting from surface defects. Understanding how liquid repellence varies is key to enabling researchers to design robust anti-biofouling surfaces that can be used on medical devices with internal surfaces (such as catheters and colostomy bags) and medical-grade metals against aggressive contamination and corrosion.
由于生物医学设备的污染导致的医院获得性感染的显著发生率是导致住院时间延长和死亡的主要公共卫生威胁,在过去二十年中引起了广泛关注。例如,留置导尿管是大多数医院获得性尿路感染(UTI)的原因,其占所有医院获得性感染的约35-40%。其次是手术部位感染,占所有医院感染的20%。这些感染的发病机制与器械/手术工具表面对细菌粘附和微生物定植的易感性有关。在这些情况下,细菌通过诸如外科器械和导管(例如,沿着泌尿道迁移到膀胱和肾脏)通过液体如污染的尿液、血液甚至水/湿气的扩散和粘附而变得非常容易。然而,由于对生物医学设备表面(包括外部和内部)的复杂生理流体的润湿和粘附的关注和理解不足,因此在防止污垢相关感染方面的进展相当有限,本提案旨在深入了解生物医学设备相关的抗生物污垢表面的润湿和粘附。“润湿”是指沉积在表面上的液体如何扩散。润湿现象受界面张力和表面结构控制。在液体的液滴在非光滑表面上的情况下,液滴可以形成大致球形形状,表现出接近180度的接触角。这允许与液体排斥表面接触的液滴容易地滑动/滚下并去除表面污染物。相比之下,液滴将在完全润湿的固体表面上自发地扩散以形成薄膜。在基于润湿的应用中的最新进展已经证明,具有极端液体排斥性的表面具有促进抗生物污垢特性的巨大潜力。这项工作将展示具有改进的耐久性和抗生物污染性能的表面的设计和应用,从而可以操纵润湿和粘附行为。首先,我们将使用最先进的制造技术来制备各种液体排斥表面。这将允许我们比较和优化制造的表面图案的液体排斥性,从而防止液体刺穿到制造的表面结构中,以避免污染和腐蚀。具体来说,我们将研究复杂液体(包括尿液和血液)的润湿和粘附行为,以促进超液体排斥表面的发展。我们将开发方法来测试表面特性如何受到与各种液体相互作用的影响。在适用的情况下,我们将评估与污染液体相互作用前后表面缺陷的影响。这是为了通过减少由表面缺陷引起的表面相关生物膜生长来改善固有的生物相容性。了解液体排斥性如何变化是使研究人员能够设计坚固的抗生物污染表面的关键,这些表面可用于具有内表面(如导管和结肠造口袋)的医疗设备和医用级金属,以防止侵蚀性污染和腐蚀。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Droplet impact on doubly re-entrant structures.
- DOI:10.1038/s41598-024-52951-2
- 发表时间:2024-02-01
- 期刊:
- 影响因子:4.6
- 作者:
- 通讯作者:
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Nan Gao其他文献
Thermally driven self-healing PEDOT conductive films relying on reversible and multiple Diels–Alder interaction
依靠可逆和多重狄尔斯-阿尔德相互作用的热驱动自修复 PEDOT 导电薄膜
- DOI:
10.1002/pol.20210750 - 发表时间:
2021 - 期刊:
- 影响因子:3.4
- 作者:
Jiarui Yu;Nan Gao;Xiaowen Xie;Xing Xin;Zhanqi Li;Shuai Chen;Jingkun Xu - 通讯作者:
Jingkun Xu
Hydrogel-Coated Microelectrode Resists Protein Passivation of In Vivo Amperometric Sensors
水凝胶涂层微电极可抵抗体内电流传感器的蛋白质钝化
- DOI:
10.1021/acs.analchem.2c04806 - 发表时间:
2023 - 期刊:
- 影响因子:7.4
- 作者:
Yongyue Yin;Hui Zeng;Shuai Zhang;Nan Gao;Rantong Liu;Shuwen Cheng;Meining Zhang - 通讯作者:
Meining Zhang
Radio Frequency Identification and Sensing: Integration of Wireless Powering, Sensing and Communication for IIoT Innovations
射频识别和传感:无线供电、传感和通信的集成,实现 IIoT 创新
- DOI:
10.1109/mcom.001.2000463 - 发表时间:
2021 - 期刊:
- 影响因子:11.2
- 作者:
Zhaozong Meng;Yirou Liu;Nan Gao;Zonghua Zhang;Zhipeng Wu;John Gray - 通讯作者:
John Gray
Effects of conductivity-enhancement reagents on self-healing properties of PEDOT:PSS films
电导增强剂对PEDOT:PSS薄膜自修复性能的影响
- DOI:
10.1016/j.synthmet.2020.116503 - 发表时间:
2020-10 - 期刊:
- 影响因子:4.4
- 作者:
Xing Xin;Zexu Xue;Nan Gao;Jiarui Yu;Hongtao Liu;Wenna Zhang;Jingkun Xu;Shuai Chen - 通讯作者:
Shuai Chen
Symmetry of spin–orbit torque induced meron annihilation
自旋轨道扭矩的对称性引起的梅子湮灭
- DOI:
10.1063/5.0188618 - 发表时间:
2024 - 期刊:
- 影响因子:4
- 作者:
Siyuan Jiang;Nan Gao - 通讯作者:
Nan Gao
Nan Gao的其他文献
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