抗孕/性交后药物的合成-猫眼课题宝

抗孕/性交后药物的合成

批准号：

3651040

负责人：

MITCHELL AVERY

金额：

$16.56万

依托单位：

SRI INTERNATIONAL

依托单位国家：

美国

项目类别：

财政年份：

1984

资助国家：

美国

项目状态：

已结题

起止时间：

1984-09-01 至 1986-08-31

来源：

https://reporter.nih.gov/project-details/3651040

关键词：

chemical structure function drug design /synthesis /production drug screening /evaluation female antifertility drug postcoital contraceptive progesterone analog

中文摘要

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英文摘要

The proposed research is a comprehensive twenty-four month synthetic and biological testing program aimed at the development of novel antiprogestational agents that will interfere with progesterone receptor utilization and that are based on the Roussel lead compound RU-38486. The proposed research may lead to the development of new derivatives of RU-38486 that show significantly improved oral or antiprogestational potency and have better pharmacokinetic and solubility characteristics thus providing new, highly effective, and safe contraceptive agents.

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