心肌梗塞溶栓的临床试验-猫眼课题宝

心肌梗塞溶栓的临床试验

批准号：

3660025

负责人：

JAMES T WILLERSON

金额：

$12.5万

依托单位：

UT SOUTHWESTERN MEDICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

1983

资助国家：

美国

项目状态：

已结题

起止时间：

1983-07-15 至 1988-09-30

来源：

https://reporter.nih.gov/project-details/3660025

关键词：

cardiotonic agents cooperative study coronary vasodilator drug administration routes drug adverse effect fibrinolytic agents fibrinolytic therapy heart disorder diagnosis heart imaging /visualization /scanning heart motion human subject human therapy evaluation intracardiac volume myocardial infarct sizing myocardial infarction nitroglycerin radionuclide diagnosis

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英文摘要

Assess the efficacy of a thrombolytic agent in reducing infarct size and thereby improving ventricular function and subsequent morbidity and mortality. The primary endpoint will be total mortality during the follow up period. Secondary endpoints include determination of the: effect of thrombolytic therapy on left ventricular ejection fraction;proportion of patients suspected of having myocardial infarction with complete versus incomplete occlusion of the infarct related artery; time limits for successful reperfusion including differences according to the route of administration; and frequency and severity of adverse effects of intracoronary and intravenous administration of thrombolytic agents in patients with acute infarction.

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