Control of germline progenitor cell fate and fertility by the mTORC1 signaling pathway

许多成人组织的维持和修复依赖于稀有的干细胞群体。生殖系干细胞对男性生育能力至关重要，尽管对这些细胞的控制机制知之甚少。我们已经确定了促进生长的mTORC1通路在生殖系干细胞功能调节中的关键作用。我们对生殖系细胞这一途径的上游调控因子和下游靶点的研究有望为不孕不育、组织再生和癌症提供独特的见解。

Maintenance and repair of many adult tissues is dependent on a rare population of stem cells. Germline stem cells are essential for male fertility although the mechanisms controlling these cells are poorly understood. We have identified a key role for the growth-promoting mTORC1 pathway in regulation of germline stem cell function. Our studies of upstream regulators and downstream targets of this pathway in germline cells promise unique insight into infertility, tissue regeneration and cancer.