Control of germline progenitor cell fate and fertility by the mTORC1 signaling pathway

mTORC1 信号通路控制生殖祖细胞命运和生育力

• 批准号: nhmrc : 1062197
• 负责人: Dr Robin Hobbs
• 金额: $ 37.59万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-germline-progenitor-signaling-pathway/454965
• 关键词: Control; germline; progenitor; cell; fate

Maintenance and repair of many adult tissues is dependent on a rare population of stem cells. Germline stem cells are essential for male fertility although the mechanisms controlling these cells are poorly understood. We have identified a key role for the growth-promoting mTORC1 pathway in regulation of germline stem cell function. Our studies of upstream regulators and downstream targets of this pathway in germline cells promise unique insight into infertility, tissue regeneration and cancer.

许多成人组织的维持和修复依赖于罕见的干细胞群体。生殖系干细胞对男性生育力至关重要，尽管控制这些细胞的机制知之甚少。我们已经确定了促进生长的mTORC 1通路在调节生殖系干细胞功能中的关键作用。我们对生殖细胞中这一通路的上游调节因子和下游靶点的研究有望对不育、组织再生和癌症有独特的见解。