Role of Plzf – Sall4 interactions in germline progenitor function and development

Plzf → Sall4 相互作用在种系祖细胞功能和发育中的作用

• 批准号: nhmrc : 1046863
• 负责人: Dr Robin Hobbs
• 金额: $ 37.68万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-plzf-sall4-function-development/111882
• 关键词: Role; Plzf; Sall4; interactions; germline

PLZF and SALL4 are critical stem cell factors and mutations in these genes are associated with developmental defects and cancer. SALL4 mutations are responsible for the malformation disease Duane-radial ray syndrome, while PLZF mutations lead to severe defects in the skeleton and gonads. We surprisingly found that PLZF and SALL4 interact and oppose each other’s functions. Our study of PLZF–SALL4 crosstalk will provide important insight into infertility, developmental disorders and cancer.

PLZF 和 SALL4 是关键的干细胞因子，这些基因的突变与发育缺陷和癌症相关。 SALL4突变导致畸形疾病杜安放射状综合征，而PLZF突变导致骨骼和性腺的严重缺陷。我们惊讶地发现 PLZF 和 SALL4 相互作用并且彼此相反的功能。我们对 PLZF-SALL4 串扰的研究将为不孕症、发育障碍和癌症提供重要的见解。