Role of Plzf – Sall4 interactions in germline progenitor function and development

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PLZF and SALL4 are critical stem cell factors and mutations in these genes are associated with developmental defects and cancer. SALL4 mutations are responsible for the malformation disease Duane-radial ray syndrome, while PLZF mutations lead to severe defects in the skeleton and gonads. We surprisingly found that PLZF and SALL4 interact and oppose each other’s functions. Our study of PLZF–SALL4 crosstalk will provide important insight into infertility, developmental disorders and cancer.