CHILDREN'S CANCER RESEARCH: THE BIOLOGY OF NEUROBLASTOM

儿童癌症研究中心(CCRC)过去的项目 涵盖了对儿科肿瘤学问题的多方面方法。 该计划项目现在将重点放在以下问题之一： 神经母细胞瘤生物学，在分子水平上研究。计划 实验室和临床科学家已经开发出了相当多的专业知识 通过多年的合作与这种肿瘤进行了合作。我们现在希望 通过四个相互交错的实验室项目继续和扩展这项工作 这是在过去赠款年度取得的成果的基础上制定的。所有人，都在 转而，从卓越的临床基础和访问 宾夕法尼亚大学细胞中心，因此作为核心 资源。这四个项目涉及(1)myc癌基因产物：结构 和在神经母细胞瘤中的功能；(2)膜糖蛋白 神经母细胞瘤；(3)神经免疫反应的分子基础 抗原：人类白细胞抗原-A、B、C的表达、调控及功能 神经母细胞瘤；(4)转移性神经母细胞瘤 与自体骨髓移植的关系。这些研究试图 确定正常神经细胞转化为 他们的恶行，以及这些事件与 观察神经母细胞瘤细胞的行为。我们的研究也在寻找方法 程序化实验室观察的临床应用 参与者，让更多患有这种肿瘤的儿童能够被治愈。(IB)

The program at the Children's Cancer Research Center (CCRC) in the past encompassed a multifaceted approach to the problems of pediatric oncology. This program project now focuses sharply on one of these problems: the biology of neuroblastoma, studied at the molecular level. Program laboratory and clinical scientists have developed considerable expertise with this neoplasm through many years of collaboration. We now wish to continue and extend this work through four interlacing laboratory projects which build on results obtained during past grant years. All of them, in turn, derive strength from an outstanding clinical base and access to the University of Pennsylvania Cell Center which therefore serve as core resources. The four projects concern (1) myc oncogene products: structure and function in neuroblastoma; (2) membrane glycoproteins specific to neuroblastoma; (3) molecular bases of the immune response to neural antigens: expression, modulation, and function of HLA-A,B,C in neuroblastoma; and (4) cell surface markers of metastatic neuroblastoma in relation to autologous marrow transplantation. These studies seek to determine the molecular bases for transformation of normal neural cells to their malignant counterparts, and the relationship of these events to the observed behavior of the neuroblastoma cell. Our studies also seek means of exploiting for clinical use the laboratory observations made by program participants, so that more children with this neoplasm can be cured. (IB)