CHILDREN'S CANCER RESEARCH: THE BIOLOGY OF NEUROBLASTOM

儿童癌症研究中心（CCRC）过去的项目 包含了一个多方面的方法来解决儿科肿瘤学的问题。 这个计划项目现在集中在这些问题之一： 神经母细胞瘤的生物学，在分子水平上进行研究。 程序 实验室和临床科学家已经发展了相当多的专业知识 通过多年的合作， 我们现在希望 通过四个交错的实验室项目继续并扩展这项工作 这是建立在过去赠款年度取得的成果基础上的。 所有这些，在 转，从一个优秀的临床基础和获得的力量 宾夕法尼亚大学细胞中心，因此作为核心 资源 这四个项目涉及（1）myc癌基因产物：结构 在神经母细胞瘤中的作用;（2）特异性膜糖蛋白， 神经母细胞瘤免疫反应的分子基础 抗原：HLA-A、B、C在免疫缺陷病毒中的表达、调节和功能 神经母细胞瘤;和（4）转移性神经母细胞瘤的细胞表面标志物， 与自体骨髓移植有关。 这些研究旨在 确定正常神经细胞转化为 他们的恶性同行，以及这些事件的关系， 观察神经母细胞瘤细胞的行为。 我们的研究还寻求 利用临床使用的实验室观察， 参与者，使更多的儿童与这种肿瘤可以治愈。 （IB）

The program at the Children's Cancer Research Center (CCRC) in the past encompassed a multifaceted approach to the problems of pediatric oncology. This program project now focuses sharply on one of these problems: the biology of neuroblastoma, studied at the molecular level. Program laboratory and clinical scientists have developed considerable expertise with this neoplasm through many years of collaboration. We now wish to continue and extend this work through four interlacing laboratory projects which build on results obtained during past grant years. All of them, in turn, derive strength from an outstanding clinical base and access to the University of Pennsylvania Cell Center which therefore serve as core resources. The four projects concern (1) myc oncogene products: structure and function in neuroblastoma; (2) membrane glycoproteins specific to neuroblastoma; (3) molecular bases of the immune response to neural antigens: expression, modulation, and function of HLA-A,B,C in neuroblastoma; and (4) cell surface markers of metastatic neuroblastoma in relation to autologous marrow transplantation. These studies seek to determine the molecular bases for transformation of normal neural cells to their malignant counterparts, and the relationship of these events to the observed behavior of the neuroblastoma cell. Our studies also seek means of exploiting for clinical use the laboratory observations made by program participants, so that more children with this neoplasm can be cured. (IB)