NATIONAL WILMS' TUMOR STUDY-4

现代治疗方法极大地提高了患者的存活率。 儿童肾母细胞瘤发生率(WT)。通过手术进行综合治疗， 放射治疗和化疗现在治愈了90%的良性疾病患者 组织学WT。肾肿瘤组织学不良者，尤其是 那些有转移的人，无论是同步的还是异时的，都处于较高的 风险。他们的存活率在50%-65%之间，显然更好的治疗方法 都是需要的。与此同时，所有的疗法都有其相关的风险和 并发症，有些对医务人员来说是昂贵和繁重的 这个家庭。对前景良好的儿童的精细化治疗是 因此需要提高效率，降低风险和成本。NWTS-4 旨在通过更好地理解 儿童肾肿瘤的流行病学及近期疗效观察 成功的治疗，同时进行新疗法的临床试验。 这些试验解决了以下问题：单次每日剂量的 在较短的时间内更频繁地给予有效的化疗药物 在降低成本和家庭压力的同时改善前景？这个 因此，NWTS承担了一项新的任务：减少社会经济 治疗的负担，同时继续争取更多的治疗和继续 它对Wilms‘s肿瘤延迟后果的开创性研究 治疗。

Modern treatment methods have led to major improvements in the survival rate of children with Wilms' tumor (WT). Combined therapy using surgery, radiation therapy and chemotherapy now cures 90% of patients with favorable histology WT. Those with renal tumors of unfavorable histology, especially those with metastases, either synchronous or metachronous, are at higher risk. Their survival is in the 50-65% range, and better treatments clearly are needed. At the same time, all therapies have their associated risks and complications, and some are costly and burdensome for the medical staff and the family. Refinements of therapy for children with a good outlook are therefore needed to increase efficiency, and reduce risks and costs. NWTS-4 is designed to achieve these objectives through better understanding of the renal tumors of childhood, their epidemiology and the late effects of successful therapy, while conducting clinical trials of novel therapies. These trials address the following question: Can single daily doses of effective chemotherapeutic agents given more frequently over a shorter interval improve the outlook while decreasing costs and family stress? The NWTS thus has undertaken a new task: the reduction of the socioeconomic burdens of therapy while continuing to strive for more cures and continuing its pioneering studies of the delayed consequences of Wilms' tumor treatments.