CHRONIC STRESS AND AGING INFLUENCES ON RETINAL NEURONS

慢性压力和衰老对视网膜神经元的影响

• 批准号: 3960160
• 负责人: WENDALL K O'STEEN
• 金额: --
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3960160
• 关键词: aging; cell death; hormone regulation /control mechanism; neuroendocrine system; radioimmunoassay; retina degeneration; retinal bipolar neuron; stress; visual photoreceptor

The photoreceptor cells (rods and cones) in the albino rat retina degenerate with age; exposure to light equal to or greater than 300 foot-candles accelerates this process. Preliminary data indicate that hormones influence photoreceptor cell degeneration: hypophysectomy and gonadectomy both protect against the damaging effects of visable light, whereas high plasma levels of prolactin accentuate cell destruction. Preliminary data indicate that chronic stress for 8 hours/day for 7 days (but not 4 hours/day for 7 days) also affects photoreceptor cells in rats. In another pilot study, chronic stress 4 hours/day for 1 year (between 12 and 24 months of age) totally abolished the retinal photoreceptor cells and badly damaged the bipolar cells. The investigator plans to examine the retinas of animals from all projects in the program. He will perform light and EM microscopy to determine the morphological extent and localization of damage to retinal neurons induced by age, stress, or change in hormonal state. The specific aims are to correlate the type and duration of stress for different ages to the severity of retinal damage; to correlate the aging and stress-induced endocrine changes with retinal damage; and to determine periods of vulnerability to chronic stress during aging.

白化大鼠视网膜的感光细胞（视杆细胞和视锥细胞）退化