NEUROANATOMY/REGENERATION RELATED TO SPINAL CORD INJURY

在包括人类在内的成年哺乳动物中，严重的脊髓损伤 整个病变的神经纤维连续性完全中断会导致 损伤平面以下的永久性功能丧失。 直到最近，还没有显示出结构性的 成人完全性脊髓损伤后的功能恢复 哺乳动物。使用一种新的脊髓修复策略 Olson已经证明了在成年大鼠身上这是可能的。 全脊髓横断加5-脊髓切除截瘫 Mm长的脊髓节段在TO水平，以获得 结构和功能恢复程度，包括后肢 运动、重量支持和感觉。修复策略包括 五个关键要素： 应用多根精细的周围神经移植桥接 损伤： B.将再生神经纤维从白质重新路由至灰质 物质；使用精确定义的神经移植物的位置： C.使用基于纤维蛋白的组织胶稳定植入区： D.使用缓释形式的酸性成纤维细胞生长因子： 脊柱的外部稳定。 用逆行轴突追踪法显示，神经纤维 从脑干和其他区域的许多中心再生。 皮质脊髓束也有再生。 基于郑博士和奥尔森博士发表的积极结果 (郑曹和奥尔森：科学273,510-513,1995)新实验 现已提出。除了生成进一步的基础之外 解读修理策略，可以有几个新的方面 研究，例如是否有改变的传导跨越 损伤面积以及特异性和地形性方面 再生纤维束的功能。

In adult mammals including man, severe spinal cord injury with complete disruption of nerve fiver continuity across the lesion leads to permanent loss of function below the level of the lesion. Until recently, there had been no demonstration of structural of functional recovery across a complete spinal cord lesion in an adult mammal. Using a novel spinal cord repair strategy Drs. Cheng and Olson have demonstrated that it is possible in adult rats made paraplegic by complete spinal cord transection and removal of a 5- mm-long segment of the spinal cord at the level of To, to obtain a degree of structural and functional recovery including hindlimb locomotion, weight support and sensation. The repair strategy involves five key elements: a. The use of multiple 918) fine peripheral nerve graft bridges across the lesion: b. Rerouting regenerating nerve fibers from white matter to grey matter; using precisely defined positioning of the nerve grafts: c. Stabilizing the engrafted area with a fibrin-based tissue glue: d. The use of acidic fibroblast growth factor in slow-release form: e. External stabilization of the vertebral column. Using retrograde axon-tracing methods, it was shown that nerve fibers regenerate from many centers in the brainstem and other areas. There is also regeneration of the corticospinal tract. Based on the positive results published b Dr. Cheng and Olson (Cheng, Cao & Olson: Science 273, 510-513, 1995) new experiments are now proposed. In addition to generating a further basis for interpretation of the repair strategy, several new aspects can be studied, such as whether or not there is a altered conduction across the injured area as well as aspects of specificity and topography of function of regenerated fiber tracts.