Control of Immunoreceptor Assembly and Function by Intramembrane Sequence Elements

膜内序列元件对免疫受体组装和功能的控制

• 批准号: nhmrc : 1011352
• 负责人: A/Pr Matthew Call
• 金额: $ 26.88万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-immunoreceptor-assembly-sequence-elements/109577
• 关键词: Control; Immunoreceptor; Assembly; Function; Intramembrane

The cells of the immune system constantly survey their environment for changes that indicate damage. To sense their surroundings cells employ a host of receptors that are associated with signalling adapter proteins that initiate signalling cascades inside the cell when receptors bind ligands. This project seeks to determine the structural mechanisms of signal propagation across the plasma membrane of immune cells.

免疫系统的细胞不断地调查它们的环境，以寻找指示损伤的变化。为了感知它们的周围环境，细胞使用与信号适配器蛋白相关的大量受体，当受体结合配体时，信号适配器蛋白在细胞内启动信号级联。该项目旨在确定免疫细胞质膜信号传播的结构机制。