SYNTHETIC PEPTIDES AS STRUCTURAL PROBES
合成肽作为结构探针
基本信息
- 批准号:2306327
- 负责人:
- 金额:$ 43.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1993
- 资助国家:美国
- 起止时间:1993-03-31 至 1998-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Isolation of enkephalins has generated the hope that the opioid peptides
or related compounds may provide the basis for the development of useful
drugs for the treatment of opiate addiction. It has been repeatedly
demonstrated that the three dimensional structure of opioids plays a
critical role in governing their biological activities. The first step
in the design of receptor specific and receptor subtype specific ligands,
and new medications, is conformational analyses of active compounds. X-
ray crystallographic and related conformational studies of the peptides
will help to deduce the three dimensional conformation and these methods
provide the most reliable information on molecular structure. By
combining X-ray data with physicochemical data, theoretical analysis
data, and data from biochemical and pharmacological studies, design of
new ligands and new medications with specific biological properties is
feasible. At present, a large number of conformationally restricted
peptidomimetics have been synthesized by various research laboratories,
and some of these compounds have exceptionally high receptor
specificities. These serve as ideal interesting biological activities.
Despite a high degree of interest in X-ray crystallographic studies,
progress in this area has been very limited due to the high price of
peptides in the first place, and lack of availability of crystalline
products in the second. In order to provide pure and crystalline opioid
peptides to researchers for NIDA supported studies, NIDA plans to
maintain an inventory of about 10-15 peptides and their intermediates.
Through this contract NIDA plans to supply chemically pure, racemization-
free peptides primarily to NIDA grantees and at the same time maintain
capability to rapidly synthesize, on demand, new ligands or new
medications as the necessity arises. In summary, the contract provides
valuable research chemicals for drug abuse researchers.
脑啡肽的分离产生了希望,
或相关化合物可以为开发有用的
治疗鸦片成瘾的药物。 屡遭
表明阿片类药物的三维结构起着重要作用。
在控制其生物活动中起着关键作用。 第一步
在受体特异性和受体亚型特异性配体的设计中,
和新药物,是活性化合物的构象分析。 X-的
肽的X射线晶体学和相关构象研究
将有助于推断三维构象和这些方法
提供分子结构的最可靠信息。 通过
结合X射线数据和物理化学数据,理论分析
生物化学和药理学研究的数据,
具有特定生物学特性的新配体和新药物,
可行 目前,大量构象受限的
肽模拟物已经由各种研究实验室合成,
其中一些化合物有非常高的
特殊性 这些都是理想的有趣的生物活动。
尽管人们对X射线晶体学研究很感兴趣,
这一领域的进展非常有限,原因是
首先是肽,缺乏晶体
产品在第二。 为了提供纯净的晶体阿片类药物
肽的研究人员为NIDA支持的研究,NIDA计划,
保持约10-15种肽及其中间体的库存。
通过这份合同,NIDA计划提供化学纯,外消旋-
免费肽主要是NIDA赠款,同时保持
能够按需快速合成新配体或新的
药物治疗,如有必要。 总之,合同规定,
对药物滥用研究人员来说是有价值的研究化学品。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('GEORGE A BRINE', 18)}}的其他基金
SYNTHETIC PEPTIDES AS STRUCTURAL PROBES FOR PRECLINICAL
合成肽作为临床前结构探针
- 批准号:
6031429 - 财政年份:1998
- 资助金额:
$ 43.2万 - 项目类别:
SYNTHETIC PEPTIDES AS STRUCTURAL PROBES FOR PRECLINICAL
合成肽作为临床前结构探针
- 批准号:
2767705 - 财政年份:1998
- 资助金额:
$ 43.2万 - 项目类别:
SYNTHETIC PEPTIDES AS STRUCTURAL PROBES FOR PRECLINICAL
合成肽作为临床前结构探针
- 批准号:
6261438 - 财政年份:1998
- 资助金额:
$ 43.2万 - 项目类别:
COMPOUND IDENTIFICATION, ACQUISITION & OPERATIONS SUPPOR
化合物鉴定、采集
- 批准号:
6194228 - 财政年份:1995
- 资助金额:
$ 43.2万 - 项目类别:
COMPOUND IDENTIFICATION, ACQUISITION & OPERATIONS SUPPOR
化合物鉴定、采集
- 批准号:
2892669 - 财政年份:1995
- 资助金额:
$ 43.2万 - 项目类别:
COMPOUND IDENTIFICATION, ACQUISITION & OPERATIONS SUPPOR
化合物鉴定、采集
- 批准号:
2306485 - 财政年份:1995
- 资助金额:
$ 43.2万 - 项目类别:
COMPOUND IDENTIFICATION, ACQUISITION & OPERATIONS SUPPOR
化合物鉴定、采集
- 批准号:
2658884 - 财政年份:1995
- 资助金额:
$ 43.2万 - 项目类别:
COMPOUND IDENTIFICATION, ACQUISITION & OPERATIONS SUPPOR
化合物鉴定、采集
- 批准号:
2834306 - 财政年份:1995
- 资助金额:
$ 43.2万 - 项目类别:
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SYNTHETIC PEPTIDES AS STRUCTURAL PROBES FOR PRECLINICAL
合成肽作为临床前结构探针
- 批准号:
6031429 - 财政年份:1998
- 资助金额:
$ 43.2万 - 项目类别:
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合成肽作为临床前结构探针
- 批准号:
2767705 - 财政年份:1998
- 资助金额:
$ 43.2万 - 项目类别:
SYNTHETIC PEPTIDES AS STRUCTURAL PROBES FOR PRECLINICAL
合成肽作为临床前结构探针
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6261438 - 财政年份:1998
- 资助金额:
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Structural and Synthetic studies of biologically active natural glycoconjugates and peptides
生物活性天然糖复合物和肽的结构和合成研究
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- 资助金额:
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Grant-in-Aid for General Scientific Research (A)