MIRA - MINOCYCLINE IN RHEUMATOID ARTHRITIS

MIRA - 米诺环素治疗类风湿性关节炎

• 批准号: 2298247
• 负责人: DAVID KAPLAN
• 金额: $ 10.81万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-15 至 1994-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2298247
• 关键词: antiarthritic agent; clinical trials; drug adverse effect; human subject; human therapy evaluation; rheumatoid arthritis; skeletal disorder chemotherapy

This is a research contract to established a clinical center to participate in a multicenter, randomized, double-blind, placebo controlled clinical trial that will assess the efficacy of minocycline in the treatment of rheumatoid arthritis (RA). The objectives of the proposed study are to determine whether minocycline is an effective therapy for the treatment of RA and to determine the frequency and severity of adverse effects of chronic minocycline therapy in patients with RA. Approximately 200 patients with RA will be randomized into an actively treated group that would receive a capsule containing 100 mg. of minocycline twice a day and a control group that would placebo capsules for one year. The primary measure of outcome will be an assessment of joint swelling and tenderness.

这是一个研究合同，建立一个临床中心， 在一项多中心、随机、双盲、安慰剂对照临床试验中， 试验将评估米诺环素治疗 类风湿性关节炎（RA）。 拟议研究的目的是 确定米诺环素是否是治疗以下疾病的有效疗法： RA，并确定不良反应的频率和严重程度 长期米诺环素治疗类风湿关节炎的疗效观察 大约200 RA患者将被随机分配到一个积极治疗组， 将接受含有100 mg的胶囊。二甲胺四环素一天两次 对照组服用安慰剂胶囊一年。 主 结果的测量将是对关节肿胀和压痛的评估。