Ultrasound-triggered mineralization: building a technology for non-union bone fracture repair

超声触发矿化:建立骨不连修复技术

基本信息

  • 批准号:
    EP/X022676/1
  • 负责人:
  • 金额:
    $ 26万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Fellowship
  • 财政年份:
    2023
  • 资助国家:
    英国
  • 起止时间:
    2023 至 无数据
  • 项目状态:
    已结题

项目摘要

Non-union bone fractures are a clinical complication that occurs when broken bones fail to heal after a prolonged period of time,which places a tremendous burden upon the patient, society, and the healthcare economy. The most common treatment involves theintroduction of solid grafts into the defect site, however, these methods require highly invasive surgical procedures that have clinicaland economic drawbacks. ULTRABONE will output an innovative method with the potential to form a new regenerative procedure toaccelerate and improve the healing of non-union bone fractures via minimally invasive surgery. This method will use focusedultrasound to remotely trigger the precipitation of apatite through stimulated release of liposomal ions. This remote mineralizationwill be incorporated within a granular hydrogel composed of high concentration collagen. This biomaterial will provide therheological properties for percutaneous injection and in situ setting, the interstitial porosity and material cues to support cell invasionand vascularization, and the high-density fibrillar network to nucleate and grow apatite at a size, distribution, and morphology that ispresent in native bone. This work program will develop the concept of ultrasound-triggered mineralization, integrate it within thegranular hydrogel, and model the regenerative capability of the system in vitro, in readiness for future preclinical testing.
骨不连是指骨折长期不愈合,给患者、社会和医疗保健经济带来巨大负担的临床并发症。最常见的治疗方法包括向缺损处引入固体移植物,然而,这些方法需要高度侵入性的外科手术,具有临床和经济上的缺点。ULTRABONE将输出一种创新的方法,有可能形成一种新的再生程序,通过微创手术加速和改善骨不连骨折的愈合。这种方法将使用聚焦超声通过脂质体离子的刺激释放来远程触发磷灰石的沉淀。这种远程矿化将被结合到由高浓度胶原蛋白组成的颗粒状水凝胶中。这种生物材料将提供用于经皮注射和原位植入的热流变性能、支持细胞侵袭和血管形成的间质孔隙率和材料线索,以及以天然骨中存在的尺寸、分布和形态成核和生长磷灰石的高密度纤维网络。这项工作计划将开发超声触发矿化的概念,将其集成到颗粒水凝胶中,并对系统的体外再生能力进行建模,为未来的临床前测试做好准备。

项目成果

期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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James Armstrong其他文献

PHARMACOGENETICS OF NEGATIVE SYMPTOM RESPONSE TO ANTIPSYCHOTIC DRUGS - THE ROLE OF 5-HT SYSTEMS
  • DOI:
    10.1016/s0920-9964(08)70779-5
  • 发表时间:
    2008-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Gavin Reynolds;James Armstrong;Suzanne Barrett;Ciaran Mulholland;Richard Anderson;Rosalind McCaul;Teresa Rushe;Stephen Cooper
  • 通讯作者:
    Stephen Cooper
Specification and verification of reactive system behaviour: The Railroad Crossing example
  • DOI:
    10.1007/bf00360339
  • 发表时间:
    1996-03-01
  • 期刊:
  • 影响因子:
    1.300
  • 作者:
    James Armstrong;Leonor Barroca
  • 通讯作者:
    Leonor Barroca
Tracheal obstruction in a child with a posterior mediastinal mass
Surpassing the strength of metallogels with a rigid, amorphous metal-rich material formulation
刚性、非晶态富金属材料配方超越金属凝胶的强度
  • DOI:
    10.1016/j.xcrp.2023.101738
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    8.9
  • 作者:
    James Armstrong;Patrick Shea;Cameron C. Cornell;Taylor Bryson;Harris E. Mason;Keith D. Morrison;M. Tofanelli;James P. Lewicki;Brandon C. Wood;Bradley F. Guilliams;W. S. Compel;C. Ackerson
  • 通讯作者:
    C. Ackerson
Atmospheric monitoring of a perfluorocarbon tracer at the 2009 ZERT Center experiment
  • DOI:
    10.1016/j.atmosenv.2011.11.024
  • 发表时间:
    2012-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Natalie Pekney;Arthur Wells;J. Rodney Diehl;Matthew McNeil;Natalie Lesko;James Armstrong;Robert Ference
  • 通讯作者:
    Robert Ference

James Armstrong的其他文献

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{{ truncateString('James Armstrong', 18)}}的其他基金

Development of a computational model of synaptome architecture.
突触体结构计算模型的开发。
  • 批准号:
    BB/X009343/1
  • 财政年份:
    2023
  • 资助金额:
    $ 26万
  • 项目类别:
    Research Grant
Symmetry-breaking Technologies for Cerebral Organoid Engineering
脑类器官工程的对称性破缺技术
  • 批准号:
    MR/V024965/1
  • 财政年份:
    2021
  • 资助金额:
    $ 26万
  • 项目类别:
    Fellowship
Engineering vascularised and aligned tissues using ultrasound cell patterning
使用超声细胞图案设计血管化和排列的组织
  • 批准号:
    MR/S00551X/1
  • 财政年份:
    2018
  • 资助金额:
    $ 26万
  • 项目类别:
    Fellowship
A Systems Biological Approach to Elucidate Local Protein Synthesis Code in Plasticity and Memory
阐明可塑性和记忆中局部蛋白质合成代码的系统生物学方法
  • 批准号:
    BB/I004491/1
  • 财政年份:
    2010
  • 资助金额:
    $ 26万
  • 项目类别:
    Research Grant
Structured and graphical queries for Drosophila neuroscience data
果蝇神经科学数据的结构化和图形查询
  • 批准号:
    BB/G02247X/1
  • 财政年份:
    2009
  • 资助金额:
    $ 26万
  • 项目类别:
    Research Grant
Rapid Development and Testing of Behavioral Models
行为模型的快速开发和测试
  • 批准号:
    9120620
  • 财政年份:
    1992
  • 资助金额:
    $ 26万
  • 项目类别:
    Continuing Grant
Chip Level Modeling of Digital Systems (Computer Research)
数字系统的芯片级建模(计算机研究)
  • 批准号:
    8420687
  • 财政年份:
    1985
  • 资助金额:
    $ 26万
  • 项目类别:
    Standard Grant
Efficient Mechanization of Higher Radix Computational Systems
高基数计算系统的高效机械化
  • 批准号:
    7825180
  • 财政年份:
    1979
  • 资助金额:
    $ 26万
  • 项目类别:
    Standard Grant
Instructional Improvement Relating to Wood Technology
与木材技术相关的教学改进
  • 批准号:
    7813362
  • 财政年份:
    1978
  • 资助金额:
    $ 26万
  • 项目类别:
    Standard Grant
Research Initiation - Realization of Minimum Complexity Circuits in Any Radix
研究启动-任意基数中最小复杂度电路的实现
  • 批准号:
    7609925
  • 财政年份:
    1976
  • 资助金额:
    $ 26万
  • 项目类别:
    Standard Grant

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SONNETS:面向可扩展性的事件触发系统新型网络
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Single cell level elucidation of local cell death-triggered regeneration mechanism in Arabidopsis
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Molecular Mechanisms of Age-Related Skin Diseases Triggered by Age-Related Alterations in the Local Endocrine System of the Skin
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