Control of neuropeptide FF receptors on appetite and energy homeostasis

神经肽 FF 受体对食欲和能量稳态的控制

• 批准号: nhmrc : 1051111
• 负责人: Dr Lei Zhang
• 金额: $ 40.63万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-neuropeptide-ff-energy-homeostasis/112199
• 关键词: Control; neuropeptide; FF; receptors; appetite

Despite the alarming obesity epidemic, there currently exists no effective long-term treatment for obesity. Neuropeptide FF and its receptor NPFF2R have an emerging role in regulating food intake and body fat stores. Results from this study will show whether NPFF2R plays an important role in regulating appetite, metabolic rate, body weight and fat stores, thus help to identify whether NPFF2R-targeted therapeutics would confer significant benefit for the long-term treatment of obesity.

尽管肥胖流行令人震惊，但目前还没有有效的长期治疗肥胖症的方法。神经肽FF及其受体NPFF2R在调节食物摄入和体内脂肪储存方面发挥着新的作用。这项研究的结果将显示NPFF2R是否在调节食欲、代谢率、体重和脂肪储存方面发挥重要作用，从而有助于确定NPFF2R靶向疗法是否对肥胖症的长期治疗具有显著好处。