Interactions between Neuropeptide FF receptor and hypothalamic neuropeptides in the regulation of energy homeostasis and obesity

神经肽FF受体与下丘脑神经肽在能量稳态和肥胖调节中的相互作用

• 批准号: nhmrc : 1039847
• 负责人: Miss Jackie Lau
• 金额: $ 6.38万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interactions-neuropeptide-ff-homeostasis-obesity/111310
• 关键词: Interactions; between; Neuropeptide; FF; receptor

Despite the alarming obesity epidemic, there currently exists no effective long-term treatment for obesity. Neuropeptide FF and its receptor NPFF2R have an emerging role in regulating food intake and body fat stores. Results from this study will show whether NPFF2R plays an important role in regulating appetite, metabolic rate, body weight and fat stores, thus help to identify whether NPFF2R-targeted therapeutics would confer significant benefit for the long-term treatment of obesity.

尽管肥胖症流行令人担忧，但目前还没有有效的长期治疗肥胖症的方法。神经肽FF及其受体NPFF2R在调节食物摄入和体脂储存方面具有新兴作用。本研究的结果将显示NPFF 2 R是否在调节食欲、代谢率、体重和脂肪储存方面发挥重要作用，从而有助于确定NPFF 2 R靶向疗法是否会为肥胖的长期治疗带来显着益处。