Greener, more sustainable platforms for high-value recombinant protein production

GreenerRPP项目旨在显著提高欧盟生产分泌型高质量重组蛋白的能力，特别是工业酶和治疗性蛋白(生物疗法)。这两个市场的总价值每年超过3300亿美元，这些产品对医疗保健和可持续的生物经济具有巨大的意义。绿色RPP将解决这些行业中的紧迫问题，例如难以表达的蛋白质和欧洲生物技术行业迅速出现的“可持续性”问题。它将在产量和工艺设计方面带来改进，从而提高行业的效率，同时减少当前的高水平废物。它将在无数的工业和家庭环境中提供降低能源和原材料成本的工业酶。为了实现这一目标，我们将开发功能强大的新微生物和哺乳动物细胞平台，以异常高的数量和无与伦比的质量生产重组蛋白，并将一套超级生产的平台推向市场。全面的培训计划将使greenerRPP ESRS具备成为这些行业未来领导者所需的跨学科和跨部门技能，同时强调各级的可持续性和性别多样性维度原则。最后，该计划解决了生物技术领域的严重全球不平等：重组蛋白生产主要在高收入国家进行(或由高收入国家外包)，使低收入/中等收入国家处于巨大的劣势。绿色伙伴关系包括一系列东南亚机构作为联系伙伴，以发展一个具有知识交流条件的全球网络，以促进这些国家自己的制造计划。因此，绿色RPP ESRS将促进欧洲工业部门的发展，使其变得更加绿色，并向低收入国家伸出援手。欧洲工业部门对社会的重要性从未像现在这样重要。

The greenerRPP project aims to markedly enhance the EU's capacity for the production of secreted high-quality recombinantproteins, especially industrial enzymes and therapeutic proteins (biotherapeutics). The combined markets are in excess of $330 billionp.a., and the products are of massive significance for healthcare and a sustainable bio-based economy. greenerRPP will addressurgent problems in these industries, such as difficult-to-express proteins and the rapidly-emerging issue of 'sustainability' in theEuropean biotechnology industry. It will deliver improvements in yield and process design that increase the industry's effectivenesswhile simultaneously reducing high current levels of waste. It will deliver industrial enzymes that reduce energy and raw materialcosts in countless industrial and domestic settings. To achieve this, we will develop powerful new microbial and mammalian cellplatforms that produce recombinant proteins in unusually high quantities and in unparalleled quality, and bring to market a suite ofsuper-producing platforms.A comprehensive training programme will equip greenerRPP ESRs with the interdisciplinary and intersectoral skills required to befuture leaders in these industries, while emphasising sustainability and gender-diversity dimension principles at every level. Finally,the programme addresses the stark global inequality in this biotechnology sector: recombinant protein production is largely carriedout in (or outsourced by) high-income countries, placing low/middle income countries at a massive disadvantage. greenerRPPincludes a series of South East Asian Institutions as Associated Partners, to develop a global network with a knowledge exchangesecondmentprogramme that boosts these countries' own manufacturing programmes. greenerRPP ESRs will thus enhance aEuropean industrial sector that has never been more important to society, while making it 'greener' and reaching out to lower incomecountries.