Greener, more sustainable platforms for high-value recombinant protein production

greenerRPP项目旨在显著提高欧盟生产高质量分泌重组蛋白的能力，特别是工业酶和治疗性蛋白（生物疗法）。合并后的市场规模每年超过3300亿美元。这些产品对医疗保健和可持续的生物经济具有重大意义。greenerRPP将解决这些行业中的问题，比如难以表达的蛋白质和欧洲生物技术行业中迅速出现的“可持续性”问题。它将提高产量和工艺设计，提高行业效率，同时减少当前的高浪费水平。它将提供工业酶，在无数的工业和家庭环境中降低能源和原材料成本。为了实现这一目标，我们将开发强大的新型微生物和哺乳动物细胞平台，以异常高的数量和无与伦比的质量生产重组蛋白，并向市场推出一套超级生产平台。一项全面的培训方案将使绿色errpp可持续发展人员具备成为这些行业未来领导者所需的跨学科和部门间技能，同时在各级强调可持续性和性别多样性原则。最后，该计划解决了这一生物技术部门严重的全球不平等问题：重组蛋白生产主要在高收入国家进行（或由高收入国家外包），使低收入/中等收入国家处于极大的劣势。greenerrpp包括一系列作为联合伙伴的东南亚机构，以发展一个具有知识交流项目的全球网络，促进这些国家自己的制造业项目。因此，绿色errpp ESRs将加强对社会从未如此重要的欧洲工业部门，同时使其“更环保”并向低收入国家伸出援手。

The greenerRPP project aims to markedly enhance the EU's capacity for the production of secreted high-quality recombinantproteins, especially industrial enzymes and therapeutic proteins (biotherapeutics). The combined markets are in excess of $330 billionp.a., and the products are of massive significance for healthcare and a sustainable bio-based economy. greenerRPP will addressurgent problems in these industries, such as difficult-to-express proteins and the rapidly-emerging issue of 'sustainability' in theEuropean biotechnology industry. It will deliver improvements in yield and process design that increase the industry's effectivenesswhile simultaneously reducing high current levels of waste. It will deliver industrial enzymes that reduce energy and raw materialcosts in countless industrial and domestic settings. To achieve this, we will develop powerful new microbial and mammalian cellplatforms that produce recombinant proteins in unusually high quantities and in unparalleled quality, and bring to market a suite ofsuper-producing platforms.A comprehensive training programme will equip greenerRPP ESRs with the interdisciplinary and intersectoral skills required to befuture leaders in these industries, while emphasising sustainability and gender-diversity dimension principles at every level. Finally,the programme addresses the stark global inequality in this biotechnology sector: recombinant protein production is largely carriedout in (or outsourced by) high-income countries, placing low/middle income countries at a massive disadvantage. greenerRPPincludes a series of South East Asian Institutions as Associated Partners, to develop a global network with a knowledge exchangesecondmentprogramme that boosts these countries' own manufacturing programmes. greenerRPP ESRs will thus enhance aEuropean industrial sector that has never been more important to society, while making it 'greener' and reaching out to lower incomecountries.