Greener, more sustainable platforms for high-value recombinant protein production

更环保、更可持续的高价值重组蛋白生产平台

• 批准号: EP/X025926/1
• 负责人: Colin Robinson
• 金额: $ 67.6万
• 依托单位: University of Kent
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX025926%2F1
• 关键词: Greener; more; sustainable; platforms; value

The greenerRPP project aims to markedly enhance the EU's capacity for the production of secreted high-quality recombinantproteins, especially industrial enzymes and therapeutic proteins (biotherapeutics). The combined markets are in excess of $330 billionp.a., and the products are of massive significance for healthcare and a sustainable bio-based economy. greenerRPP will addressurgent problems in these industries, such as difficult-to-express proteins and the rapidly-emerging issue of 'sustainability' in theEuropean biotechnology industry. It will deliver improvements in yield and process design that increase the industry's effectivenesswhile simultaneously reducing high current levels of waste. It will deliver industrial enzymes that reduce energy and raw materialcosts in countless industrial and domestic settings. To achieve this, we will develop powerful new microbial and mammalian cellplatforms that produce recombinant proteins in unusually high quantities and in unparalleled quality, and bring to market a suite ofsuper-producing platforms.A comprehensive training programme will equip greenerRPP ESRs with the interdisciplinary and intersectoral skills required to befuture leaders in these industries, while emphasising sustainability and gender-diversity dimension principles at every level. Finally,the programme addresses the stark global inequality in this biotechnology sector: recombinant protein production is largely carriedout in (or outsourced by) high-income countries, placing low/middle income countries at a massive disadvantage. greenerRPPincludes a series of South East Asian Institutions as Associated Partners, to develop a global network with a knowledge exchangesecondmentprogramme that boosts these countries' own manufacturing programmes. greenerRPP ESRs will thus enhance aEuropean industrial sector that has never been more important to society, while making it 'greener' and reaching out to lower incomecountries.

greenerRPP项目旨在显著提高欧盟生产分泌型高质量重组蛋白的能力，特别是工业酶和治疗性蛋白（生物治疗剂）。合并后的市场每年超过3300亿美元，这些产品对医疗保健和可持续的生物经济具有重要意义。绿色RPP将解决这些行业的新兴问题，如难以表达的蛋白质和欧洲生物技术行业迅速出现的“可持续性”问题。它将提高产量和工艺设计，提高行业效率，同时减少高电流水平的浪费。它将提供工业酶，在无数的工业和家庭环境中降低能源和原材料成本。为了实现这一目标，我们将开发强大的新型微生物和哺乳动物细胞平台，以异常高的数量和无与伦比的质量生产重组蛋白，并将一套超级生产平台推向市场。一项全面的培训计划将为绿色RPP ESRs提供成为这些行业未来领导者所需的跨学科和跨部门技能，同时在各级强调可持续性和性别多样性原则。最后，该计划解决了这一生物技术部门的严重全球不平等：重组蛋白生产主要在高收入国家进行（或外包），使低/中等收入国家处于巨大的劣势。绿色区域伙伴关系包括一系列东南亚机构作为联系伙伴，以建立一个全球网络，并实施一项知识交流方案，促进这些国家自己的制造业方案。因此，绿色RPP ESRs将加强欧洲工业部门，这对社会来说从未如此重要，同时使其“更加绿色”并延伸到低收入国家。