BARBADOS INCIDENCE STUDY OF EYE DISEASE (BISED)

巴巴多斯眼病发病率研究（BISED）

• 批准号: 2161629
• 负责人: MCRISTINA LESKE
• 金额: $ 82.57万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2161629
• 关键词: African Caribbean; aging; alcoholism /alcohol abuse; blood pressure; cardiovascular disorder; cataract; cooperative study; diabetes mellitus; diabetic retinopathy; dietary supplements; disease /disorder proneness /risk; eye disorder; eye disorder diagnosis; eye fundus photography; eye refractometry; family genetics; genetic markers; glaucoma; glaucoma test; hemoglobin; human middle age (35-64); human old age (65+); human population study; human subject; hypertension; interview; intraocular pressure; longitudinal human study; macular degeneration; medical records; nutrition related tag; statistics /biometry; tobacco abuse; vision tests; visual fields; visual perception

The Barbados Incidence Study of Eye Diseases (BISED) is designed to provide epidemiologic data on open-angle glaucoma (OAG) and other major causes of visual loss in black populations. It aims to determine incidence, progression and risk factors for OAG, age-related cataract, age-related macular degeneration, diabetic retinopathy and visual impairment among the population-based cohort of about 4500 persons, ages 40-86 years, who were examined from 1988-1992 as part of the Barbados Eye Study (BES). The BES was designed to measure prevalence and risk factors for each of the major eye diseases in a black population and to establish a baseline for future incidence measurements. No incidence or progression data have ever been collected on eye diseases in blacks that are based on a nationwide prevalence study with a high (85%) participation, a sufficiently large population to allow both precise estimates and risk factor assessment, and standardized and reproducible clinical and photographic protocols to measure each disease. To achieve these aims, BES participants would be re-examined to obtain ocular data (e.g., intraocular pressure, refraction, visual acuity, visual fields, lens gradings), blood pressure and anthropometric measurements, medical history and other interview data, stereo fundus photographs of the disc and macula and glycated hemoglobin, following the same BES protocol. Comparison of BES and BISED data would not only provide much needed data on incidence and progression, but would also allow risk factor evaluation and determination of relative and population attributable risks. Baseline risk factor data include cardiovascular variables, diabetes and body size, ocular variables, use of nutritional supplements, medication exposures, smoking and alcohol use, pigmentation, familial aggregation, genetic markers, demographic and health care utilization measures. The information will provide data for public health planning, understanding etiology, identifying groups at high risk and developing appropriate strategies to control visual loss. The feasibility of BISED was supported by a pilot study that had a 94% participation rate and a 91% positive response to a response to a return examination.

巴巴多斯眼病发病率研究 (BISED) 旨在 提供开角型青光眼 (OAG) 和其他主要疾病的流行病学数据 黑人视力丧失的原因。 其目的是确定 OAG、年龄相关性白内障的发病率、进展和危险因素， 年龄相关性黄斑变性、糖尿病视网膜病变和视力 约 4500 人的人群中存在损伤， 年龄在 40 岁至 86 岁之间，作为 1988 年至 1992 年期间接受检查的人 巴巴多斯眼科研究（BES）。 BES 旨在衡量患病率 以及黑人每种主要眼病的危险因素 人口并建立未来发病率的基线 测量。 尚未有发病率或进展数据 根据全国范围内的调查收集了关于黑人眼病的信息 参与率高（85%）的患病率研究，足够大 人口，以便进行精确估计和风险因素评估， 以及标准化和可重复的临床和摄影方案 来衡量每种疾病。 为了实现这些目标，BES 参与者将接受重新审查以获得 眼部数据（例如眼压、屈光度、视力、 视野、晶状体分级）、血压和人体测量 测量、病史和其他访谈数据、立体眼底 椎间盘和黄斑以及糖化血红蛋白的照片，如下 相同的 BES 协议。 BES 和 BISED 数据的比较不仅 提供了急需的有关发病率和进展的数据，但也 允许风险因素评估和确定相对和 人口归因风险。 基线风险因素数据包括 心血管变量、糖尿病和体型、眼部变量、使用 营养补充剂、药物暴露、吸烟和饮酒 使用、色素沉着、家族聚集、遗传标记、人口统计 和医疗保健利用措施。 该信息将提供 用于公共卫生规划、了解病因、识别 高危人群并制定适当的控制策略 视力丧失。 BISED 的可行性得到了试点研究的支持 参与率为 94%，积极响应率为 91% 对返回检查的答复。