HUMAN LIPOPROTEIN PATHOPHYSIOLOGY
人类脂蛋白病理生理学
基本信息
- 批准号:2216584
- 负责人:
- 金额:$ 150.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1983
- 资助国家:美国
- 起止时间:1983-05-01 至 1998-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Premature vascular disease in young hyperlipidemic subjects remains a
major unsolved health problem in terms of pathogenesis and treatment.
Recent research advances have led to new markers for genetic analysis, new
methods for studying lipoprotein metabolism and atherosclerotic disease
progression and regression, and reference values for diagnosing
hyperlipidemia. With these advances, the opportunity now exists for
further in-depth focused studies of lipoprotein physiology and
pathophysiology in genetically characterized patients with the objectives
of understanding disease mechanisms, developing better treatments, and
identifying and preventing early vascular disease. This will be
accomplished by focusing our attention on the molecular, genetic and
pathophysiological basis of the inherited dyslipoproteinemias associated
with premature coronary artery disease with particular reference to
familial combined hyperlipidemia, familial moderate hypercholesterolemia,
familial elevation of Lp(a) and the carrier state for homocysteinemia.
Coordinated studies of characterization of the pathophysiological state,
the identification of possible molecular biological defects and the
evaluation of these results in families by statistical genetic techniques
will be performed in each disorder. The role of protein mediated
intravascular modification of lipoproteins and the role of oxidation of
lipoproteins in each disorder will lead to characterization of these
genetic lipoprotein abnormalities. The Program Project, comprised of four
coordinated projects, four supporting core facilities and a
multidisciplinary team of investigators will combine the expertise in
physiology, molecular biology, biochemistry, genetics, immunochemistry,
nutrition, endocrinology, metabolism, epidemiology, and statistical
genetics, to study lipoprotein physiology and pathophysiology at several
levels of biological organization from basic molecular and cell biology
through in vivo studies in humans to studies in populations.
年轻高血压患者的早发性血管疾病仍然是一个危险因素。
在发病机制和治疗方面,这是一个尚未解决的重大健康问题。
最近的研究进展导致了用于遗传分析的新标记,
研究脂蛋白代谢和动脉粥样硬化疾病的方法
进展和消退,以及诊断的参考值
高脂血症随着这些进步,现在有机会
进一步深入研究脂蛋白生理学,
遗传特征患者的病理生理学,
了解疾病机制,开发更好的治疗方法,
识别和预防早期血管疾病。 这将是
通过将我们的注意力集中在分子,遗传和
遗传性异常脂蛋白血症的病理生理基础
患有早发性冠状动脉疾病,
家族性混合性高脂血症,家族性中度高胆固醇血症,
家族性Lp(a)升高和同型半胱氨酸血症的携带状态。
病理生理状态表征的协调研究,
鉴定可能的分子生物学缺陷,
用统计遗传学方法对家系中的这些结果进行评价
将在每种疾病中进行。蛋白质介导的作用
脂蛋白的血管内修饰和氧化的作用
脂蛋白在每种疾病将导致表征这些
遗传性脂蛋白异常 该计划由四个项目组成
协调项目、四个支助核心设施和一个
一个多学科的调查小组将联合收割机的专业知识,
生理学,分子生物学,生物化学,遗传学,免疫化学,
营养学、内分泌学、代谢学、流行病学和统计学
遗传学,研究脂蛋白生理学和病理生理学在几个
从基本的分子和细胞生物学的生物组织水平
从人体内研究到人群研究。
项目成果
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