MetRaZymes: Metal-containing Radical Enzymes

MetRaZymes：含金属自由基酶

• 批准号: EP/X032957/1
• 负责人: David Palmer
• 金额: $ 33.8万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX032957%2F1
• 关键词: MetRaZymes; Metal; containing; Radical; Enzymes

The pharmaceutical, chemical and polymer industries are cornerstones of Europe's economy. A key element for their transition to more sustainable processes and to innovative new compounds is biocatalysis. Of particular interest are metallo-enzymes, i.e. proteins that host a metal cofactor. They catalyze a multitude of redox and radical reactions. To access reactions that are unknown in nature, artificial metallo-enzymes can be created. They combine the new-to-nature catalytic activity of metal complexes with the selectivity-inducing environment of the active protein site. To develop novel biocatalysts, a highly interdisciplinary skill set is needed. MetRaZymes will create a PhD school across leading European universities that will train the next generation of scientists capable of tackling the design, development and implementation of novel enzymatic reactions in a holistic approach. It brings together computational bioscientists, bioinorganic and polymer chemists, and bioprocess engineers. Using artificial and repurposed metalloenzymes as the focal point, the ESRs will develop novel biocatalysts for radical reactions of high synthetic value, such as the late stage modification of pharmaceutical intermediates or the synthesis of polymers from renewable monomers. To train the ESRs in the needs of industrial biotechnology, the consortium includes eight of Europe's leading pharmaceutical, chemical and enzymology companies. The ESRs will benefit from a vast transferable skills training program delivered by five training partners. Highlights include a Nature Masterclass and Wikipedia workshop. Communication partners such as Wikimedia and the Industrial Biotechnology Innovation Centre will act as muliplicators for the communication of results. Moreover, the ESRs will work with artist that use biology as their way of expression to create an ARTzymes exhibition that will foster the ERS's creativity and result in a an unique form of science dialogue with the general public

制药、化学和聚合物工业是欧洲经济的基石。他们向更可持续的工艺和创新的新化合物过渡的一个关键因素是生物催化。特别感兴趣的是金属酶，即具有金属辅因子的蛋白质。它们催化大量的氧化还原和自由基反应。为了获得自然界中未知的反应，可以创建人工金属酶。它们联合收割机将金属络合物的新自然催化活性与活性蛋白质位点的选择性诱导环境相结合。为了开发新型生物催化剂，需要高度跨学科的技能。MetRaZymes将在欧洲领先的大学建立一所博士学校，培养下一代科学家，能够以整体方法解决新型酶促反应的设计、开发和实施。它汇集了计算生物科学家，生物无机和聚合物化学家以及生物工艺工程师。利用人工和再利用的金属酶作为焦点，ESRs将开发用于高合成价值的自由基反应的新型生物催化剂，例如药物中间体的后期改性或由可再生单体合成聚合物。为了培训ESRs满足工业生物技术的需求，该联盟包括八家欧洲领先的制药、化学和酶学公司。ESRs将受益于由五个培训合作伙伴提供的广泛的可转移技能培训计划。亮点包括自然大师班和维基百科研讨会。维基媒体和工业生物技术创新中心等交流合作伙伴将作为成果交流的多重传播者。此外，ERS将与使用生物学作为表达方式的艺术家合作，创建一个ARTzymes展览，以促进ERS的创造力，并与公众进行独特的科学对话