CHANGE - Cellular Homeostasis And aGeing in Connective TissuE Disease (parent application EP/X031721/1)

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The increased longevity in developed countries not necessarily goes hand in hand with amelioration of health and quality of life.Musculoskeletal, cardiovascular and neurodegenerative failure are not only hallmarks of the physical and cognitive decline in elderlypeople, but also represent common traits in several early-onset hereditary connective tissue (CT) disorders. These disorders representa unique tool for the molecular investigation of such age-related pathologies due to the specific genetic disturbance of cellularhomeostasis. The scientific objectives of CHANGE are: (i) to investigate CT disorders to identify key pathways responsible for agerelateddecline of physiological functions, being aware of gender differences (ii) to learn more about the interdependency of thesepathways leading to stereotypic cellular responses including cellular senescence. This knowledge will pave the way for developinginnovative treatment strategies for common diseases and frailty associated with ageing. To this end, we will train and establish anetwork of 10 highly-skilled early stage researchers (ESRs) equipped with scientific expertise, transferable skills and societal andenvironment awareness as a foundation for their future careers. To succeed, CHANGE has built a unique and multidisciplinarynetwork of 7 renowned academic partners and 5 companies (including 2 non-academics as associated partners) working together totrain 10 young scientists. The ESR network will address the basic biology of ageing from an interdisciplinary perspective, by deeplyinvestigating CT diseases to uncover the pillars of ageing and its multi-systemic signatures. Altogether, CHANGE will provide anintegrative map of cellular/extracellular consequences of age-related changes in cartilage, bone, muscle and vasculature asconsequences to precocious disease exposure.