PREVENTION OF BONE LOSS AND RENAL STONES DURING IMMOBILIZATION

固定期间预防骨丢失和肾结石

• 批准号: 3742845
• 负责人: CHARLES YC PAK
• 金额: --
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3742845
• 关键词: diphosphonate; disease /disorder prevention /control; drug screening /evaluation; human subject; human therapy evaluation; nephrolithiasis; osteoclasts; physiologic bone resorption; restricted physical activity

The goal of this project is to test the hypothesis that osteoclastic bone resorption is inappropriately high in immobilization, and that a third-generation diphosphonate would correct it, thereby averting bone loss and propensity for kidney stone formation. Using the model of bedrest immobilization, the effect of Olapadronate will be compared with that of placebo.

这个项目的目的是测试破骨细胞骨的假设