EFFECT OF IV ERYTHROMYCIN AND SUBCUTANEOUS OCTREOTIDE ON ANTRO-DUODENAL MOTILITY

静脉注射红霉素和皮下奥曲肽对十二指肠前运动的影响

• 批准号: 3743570
• 负责人: RICHARD W MCCALLUM
• 金额: --
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3743570
• 关键词: drug screening /evaluation; duodenum; erythromycin; gastrointestinal disorder chemotherapy; gastrointestinal motility /pressure; human subject; human therapy evaluation; intravenous administration; paralysis; peptide hormone analog; perfusion; somatostatin; stomach

Erythromycin has been shown to stimulate antral motility through motilin receptor stimulation, and serves as a beneficial therapy in gastroparetic patients. The effect of Octreotide on antral and small bowel motility is unclear. This study examines the effect of Erythromycin and Octreotide antroduodenal motility as measured by a hydrostatic perfusion device and electrogastrogram in patients with gastroparesis.

红霉素已被证明可以通过胃动素刺激胃窦运动 受体刺激，并作为胃轻瘫的有益疗法 患者。 奥曲肽对胃窦和小肠蠕动的影响是 不清楚。 本研究检验了红霉素和奥曲肽的作用 通过静压灌注装置测量的十二指肠前运动和 胃轻瘫患者的胃电图。