全反式视黄酸与干扰素联合的 I 期试验-猫眼课题宝

全反式视黄酸与干扰素联合的 I 期试验

批准号：

3744066

负责人：

KATHERINE K MATTHAY

金额：

$0.0万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3744066

关键词：

clinical trials combination cancer therapy combination chemotherapy drug administration rate /duration drug interactions drug screening /evaluation human subject human therapy evaluation interferon alpha neoplasm /cancer chemotherapy neoplasm /cancer immunotherapy neoplasm /cancer nutrition therapy nutrition related tag pediatric neoplasm /cancer retinoate vitamin therapy

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英文摘要

A body of preclinical data has provided a strong rationale for evaluating the combination of IFN-alpha with retinoic acid. The two drugs have different mechanisms of action and, when used in combination, show enhanced activity in both adult and pediatric tumor cell lines. The current study will attempt to maintain plasma all-trans-RA concentrations over time by administering drug on an intermittent schedule of three consecutive days per week, repeated weekly.

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