SPECIAL PROJECT ON RESEARCH EXCELLENCE--BREAST CANCER

卓越研究特别项目——乳腺癌

• 批准号: 2098877
• 负责人: MARC E LIPPMAN
• 金额: $ 231.52万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1995-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2098877
• 关键词: breast neoplasms; neoplasm /cancer therapy; neoplastic growth

This document describes our SPORE application entitled "Novel Targets for Prevention and Therapy of Breast Cancer". This program is based on the premise that molecules involved in the mitogenic, invasive and metastatic behavior of breast cancer as well as escape from hormone independence are identifiable and thus can be exploited for improved prognostication, therapy selection, and design of specific biologic therapies for treatment and prevention of disease. In this application a series of interactive research projects are focused on expanding our understanding of the pathogenetic significance of these molecules in breast cancer progression and exploiting this information to develop effective new strategies for breast cancer prevention and treatment. Specific targets chosen for translational research studies include heparin binding growth factors required for tumor induced angiogenesis (and thus critical in conversion from in situ to invasive breast cancer); a novel metalloproteinase secreted by breast cancer cells; newly discovered ligands of erbB2 which may play a role in breast cancer progression and therapy resistance, and the estrogen receptor. Preclinical and clinical studies of prognostic factors and therapies involving these breast cancer products are developed. A series of four novel cores is described including a tumor bank of fresh and frozen breast tumor materials, a repository of breast cancer cell lines, clinical breast cancer research resources and a unique mechanism of research coordination which support these projects and foster interaction with other institutional strengths and other SPOREs. A program for continued development of faculty committed to breast cancer research is described with specific examples of young faculty and their work which will benefit from this program. A portfolio of high priority pilot projects together with a system for prioritization and oversight is discussed which contribute directly to major SPORE projects and translational research activities. Finally, a coherent, tightly structured organization for the SPORE is described which provides accountability, flexibility and optimal interaction within the SPORE, within the institutional structure, and with other SPOREs to achieve the goal of improved outlook for women at risk of breast cancer and for patients already suffering from the disease.

本文档描述了我们的 SPORE 应用程序，标题为“Novel Targets for 乳腺癌的预防和治疗”。该计划基于 前提是参与有丝分裂、侵袭和转移的分子 乳腺癌的行为以及逃避激素独立是 可识别，因此可用于改善预测， 治疗选择和特定生物疗法的设计 和预防疾病。 在这个应用程序中一系列互动 研究项目的重点是扩大我们对 这些分子在乳腺癌进展中的发病意义 并利用这些信息制定有效的新战略 乳腺癌的预防和治疗。 选定的具体目标 转化研究包括肝素结合生长因子 肿瘤诱导的血管生成所需（因此对于转化至关重要） 从原位乳腺癌到浸润性乳腺癌）；分泌一种新型金属蛋白酶 由乳腺癌细胞引起；新发现的erbB2配体可能发挥作用 在乳腺癌进展和治疗耐药中的作用以及雌激素 受体。 预后因素的临床前和临床研究 开发了涉及这些乳腺癌产品的疗法。 A系列 描述了四个新颖的​​核心，包括新鲜和冷冻的肿瘤库 乳腺肿瘤材料、乳腺癌细胞系储存库、临床 乳腺癌研究资源和独特的研究机制 支持这些项目并促进与其他项目互动的协调 机构优势和其他孢子。 一个持续的计划 描述了致力于乳腺癌研究的教师的发展 年轻教师及其工作的具体例子将受益 从这个程序。 一系列高优先级试点项目 讨论了优先级排序和监督系统 直接为主要 SPORE 项目和转化研究做出贡献 活动。 最后，建立一个连贯、结构严密的组织 SPORE 的描述提供了责任性、灵活性和最佳性 SPORE 内部、机构结构内以及与 其他孢子，以实现改善面临风险的妇女的前景的目标 乳腺癌以及已经患有该疾病的患者。