PATHOGENESIS AND PREVENTION OF OSTEOPOROSIS

这是基础和临床项目资助计划的延续 有关骨质疏松症的研究。它包括一个管理核心， 分子组织学和转基因动物核心实验室，以及四大 项目。这些项目是1)研究性激素对人的影响 骨形成和前列腺素的产生，2)作用的研究 糖皮质激素对胶原基因表达的影响，3)新的研究进展 转基因模型用于评估激素和组织结构调节 体内骨基质合成及性激素作用的研究 细胞因子的产生和破骨细胞的形成和功能。这些 项目将与其他正在进行的研究工作密切结合在一起 骨代谢目前在加州大学进行。 康涅狄格州卫生中心及其附属机构，包括 综合临床研究中的实验室研究和临床研究 GCRC和骨质疏松症中心。程序的存在 项目是骨质疏松症在产生新研究中的关键 参与骨和骨相关研究的众多教职员工之间的互动 结缔组织代谢与肌肉骨骼疾病 机构。这导致了分子应用的新举措。 生物学和基因技术对骨质疏松症发病机制的影响。未来 计划项目赠款中的互动应有助于我们提供新的 知识并导致对发病机制的更好理解和更多 预测、预防和治疗骨质疏松的有效途径。

This is a continuation of a Program Project Grant on basic and clinical studies related to osteoporosis. It includes an administrative core, molecular histology and transgenic animal core laboratories, and four major projects. The projects are 1) studies on the effects of sex hormones on bone formation and prostaglandin production, 2) studies on the role of glucocorticoids on collagen gene expression, 3) the development of new transgenic models to assess the hormonal and constitutive regulation of bone matrix synthesis in vivo and 4) studies on the effect of sex hormones on cytokine production and osteoclast formation and function. These projects will be closely integrated with other ongoing research efforts in bone metabolism currently being carried out at the University of Connecticut Health Center and its affiliated institutions, including laboratory studies and clinical research in the General Clinical Research Center (GCRC) and the Osteoporosis Center. The existence of a Program Project is osteoporosis has been vital in generating new research interactions among the many faculty involved in studies on bone and connective tissue metabolism and musculoskeletal disease at this institution. It has led to new initiatives in the application of molecular biology and genetic techniques to the pathogenesis of osteoporosis. Future interactions in the Program Project Grant should help us to provide new knowledge and lead to a better understanding of pathogenesis and more effective approaches to prediction, prevention and therapy in osteoporosis.