CLAUDE PEPPER OLDER AMERICANS INDEPENDENCE CENTER

克劳德·佩珀美国老年人独立中心

• 批准号: 6338452
• 负责人: Lawrence Gideon Raisz
• 金额: $ 14.16万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6338452
• 关键词: aging; geriatrics; human old age (65+); musculoskeletal disorder

The emphasis of the University of Connecticut Health Center (UCHC) OAIC is musculoskeletal aging and its complications in older women. Intervention development studies (IDSs) to prevent or delay disability will be conducted, emphasizing bone health through prevention of osteoporosis and falls, coupled with aerobic and strength training. More broadly, the OAIC will create the infrastructure to support independence-promoting projects beyond musculo-skeletal aging by establishing Cores for Subject Recruitment and Retention (expert assistance in recruiting, scheduling, maintaining and retaining volunteers for OAIC and related projects; develop a registry of subjects for future studies) and for Outcomes Measurement (multidisciplinary measurement of physical performance, quality of life, bone biomarkers and cost-effectiveness) available not only to OAIC-funded projects, but also to relevant projects conducted by any UCHC research faculty. Epidemiology and Biostatistical Services will be provided for OAIC projects and activities by faculty and staff of the Epi/Biostat Core of UCHC's NIH-funded General Clinical Research Center (GCRC), supported in part by OAIC funds and in part by GCRC and UCHC contributions. Complementary IDSs will examine strategies to prevent bone loss and increase bone mass. IDS#1 will first determine the lowest dose of estrogen which will reduce bone turnover in older women; a second phase will determine if this estrogen regimen will not only reduce bone turnover, but also increase bone density and benefit other measures of health. Phase three will use molecular techniques on bone and marrow samples from a subset of study subjects to determine directly the influence of estrogen on an array of local factors known to modulate bone turnover. IDS#2 will study the effects of home exercise on bone density in older women already taking estrogen. Estrogen appears to function primarily as an anti-resorptive agent, thus preventing bone loss rather than increasing bone mass. For women on ERT who meet the new WHO criteria for low bone density, it is reasonable to consider exercise as adjunct therapy to reduce fracture risk. A major emphasis of IDS#2 is the development of a home-based exercise training program using low-cost equipment that leads to a high level of adherence and compliance. Together these investigations will address a central problem faced by older women (i.e., diminished mobility and functional status due to osteoporosis and the attendant risk of fracture). The UCHC OAIC will train and promote career development of new faculty committed to research in musculoskeletal aging and any other areas relevant to independence promotion and disability prevention for older adults by providing training, courses, mentoring and pilot project support. Finally, the OAIC will demonstrate benefits of the interventions and disseminate research findings to health professionals, to older adults and their families and to the public.

康涅狄格大学健康中心（UCHC）OAIC的重点 是老年妇女的肌肉骨骼老化及其并发症。 预防或延迟残疾的干预发展研究 将进行，强调通过预防骨骼健康， 骨质疏松症和福尔斯，再加上有氧和力量训练。 更广泛地说，OAIC将创建基础设施， 独立促进项目超越肌肉骨骼老化， 建立受试者招募和保留核心（专家 协助招聘、安排、维护和保留 OAIC和相关项目的志愿者;制定主题注册表 用于未来研究）和用于结果测量（多学科 体能、生活质量、骨生物标志物的测量 不仅向审调处资助的项目提供， 也适用于任何UCHC研究人员进行的相关项目。 将为OAIC提供流行病学和生物统计服务 Epi/Biostat核心的教职员工的项目和活动 UCHC的NIH资助的一般临床研究中心（GCRC），支持在 一部分由国际慈善组织的资金提供，一部分由全球儿童权利中心和联合国儿童权利中心的捐款提供。 补充IDS将检查预防骨质流失的策略， 增加骨量。 IDS#1将首先确定 雌激素，这将减少老年妇女的骨转换;第二阶段 将决定这种雌激素疗法是否不仅会减少骨质疏松 营业额，而且还增加骨密度和有益于其他措施， 健康 第三阶段将在骨骼和骨髓上使用分子技术 从研究受试者的子集中采集样本，以直接确定 雌激素对一系列已知调节 骨转换 IDS#2将研究家庭锻炼对骨骼的影响 已经服用雌激素的老年妇女的密度。 雌激素似乎 主要作为抗再吸收剂发挥作用， 减少而不是增加骨量。 对于在ERT中遇到 新的WHO低骨密度标准，合理考虑 运动作为辅助疗法，以降低骨折风险。 一个主要重点 IDS#2的第一个目标是开发一个以家庭为基础的运动训练计划， 使用低成本的设备，导致高水平的坚持， 合规 这些调查将共同解决一个核心问题， 老年妇女面临的问题（即，活动性和功能性降低 由于骨质疏松症和随之而来的骨折风险的状态）。 的 UCHC OAIC将培训和促进新教师的职业发展 致力于研究肌肉骨骼老化和任何其他领域 与促进老年人独立和预防残疾有关 通过提供培训、课程、指导和试点项目， 支持. 最后，OAIC将展示 干预措施和向卫生专业人员传播研究结果， 对老年人和他们的家人以及公众来说。