PROTECTIVE IMMUNITY IN HUMAN FILARIASIS

据估计，有8000万人感染了班克罗夫氏舞蹈菌和 马来丝虫，一种由蚊子传播的线虫寄生虫 热带地区的变形性淋巴丝虫病。有明确的证据表明 从动物研究来看，阶段特异性免疫可发展为丝虫病 微丝虫和三期感染性幼虫(L3)。这份ICIDR 该项目是研究丝虫病免疫力的一项雄心勃勃的尝试 在人类中对仔细定义的种群进行了纵向研究 一个高度流行的地区。 该项目的具体目标是： 1.检验人类产生保护性免疫的假设 班克罗夫特丝虫病。 2.研究人类对微丝虫病的免疫力。 3.鉴定可能成为保护性免疫靶标的寄生虫抗原 班氏五味子对L3和微丝虫的应答。 4.检验母体感染状况影响母体健康的假设 儿童对丝虫病的易感性。

An estimated 80 million people are infected with Wuchereria bancrofti and Brugia malayi, mosquito-transmitted nematode parasites that cause deforming lymphatic filariasis in the tropics. There is clear evidence from animal studies that stage-specific immunity can develop to filarial microfilariae and to third stage infective larvae (L3). This ICIDR project represents an ambitious attempt to study immunity to filariasis in humans with a longitudinal study of carefully defined populations in a highly endemic region. The SPECIFIC AIMS of this project are: 1. TO TEST THE HYPOTHESIS THAT HUMANS Develop PROTECTIVE IMMUNITY TO BANCROFTIAN FILARIASIS. 2. TO STUDY IMMUNITY TO MICROFILARIAE IN HUMANS. 3. TO IDENTIFY PARASITE ANTIGENS THAT MAY BE TARGETS OF PROTECTIVE IMMUNE RESPONSES TO L3 AND MICROFILARIAE OF WUCHERERIA BANCROFTI. 4. TO TEST THE HYPOTHESIS THAT MATERNAL INFECTION STATUS AFFECTS THE SUSCEPTIBILITY OF CHILDREN TO FILARIASIS.