PROTECTIVE IMMUNITY IN HUMAN FILARIASIS

估计有8 000万人感染了班氏吴策线虫， 马来丝虫，蚊子传播的线虫寄生虫， 热带地区的变形性淋巴丝虫病 有明确的证据 从动物研究来看，特定阶段的免疫力可以发展到丝虫病， 微丝蚴和第三期感染性幼虫（L3）。 这个ICIDR 该项目是一项雄心勃勃的研究丝虫病免疫力的尝试 在人类中，对仔细定义的人群进行了纵向研究， 一个高度流行的地区。 该项目的具体目标是： 1.为了验证人类对癌症产生免疫力的假设 班氏丝虫病。 2.研究人体对微丝蚴的免疫力。 3.鉴定可能成为抗虫免疫靶点的寄生虫抗原 班氏丝虫对L3和微丝蚴的反应 4.为了验证母体感染状况影响 儿童对丝虫病的易感性。

An estimated 80 million people are infected with Wuchereria bancrofti and Brugia malayi, mosquito-transmitted nematode parasites that cause deforming lymphatic filariasis in the tropics. There is clear evidence from animal studies that stage-specific immunity can develop to filarial microfilariae and to third stage infective larvae (L3). This ICIDR project represents an ambitious attempt to study immunity to filariasis in humans with a longitudinal study of carefully defined populations in a highly endemic region. The SPECIFIC AIMS of this project are: 1. TO TEST THE HYPOTHESIS THAT HUMANS Develop PROTECTIVE IMMUNITY TO BANCROFTIAN FILARIASIS. 2. TO STUDY IMMUNITY TO MICROFILARIAE IN HUMANS. 3. TO IDENTIFY PARASITE ANTIGENS THAT MAY BE TARGETS OF PROTECTIVE IMMUNE RESPONSES TO L3 AND MICROFILARIAE OF WUCHERERIA BANCROFTI. 4. TO TEST THE HYPOTHESIS THAT MATERNAL INFECTION STATUS AFFECTS THE SUSCEPTIBILITY OF CHILDREN TO FILARIASIS.