WOMEN AND INFANTS TRANSMISSION STUDY (WITS II)

妇女和婴儿传播研究(WITS-II)将加入 将感染艾滋病毒的孕妇和她们的婴儿合并为多中心， 以回答关键问题为目标的流行病学队列研究 与怀孕期间艾滋病毒疾病有关的问题，以及 母婴传播。此外，研究问题 与实施治疗性干预有关 人口问题将得到解决。WITS II的具体目标是1) 评估怀孕对母亲艾滋病毒进展的影响2) 确定与垂直传播相关的母体共同因素 3)评价婴儿感染的早期诊断技术 4)描述感染者中HIV疾病的自然病史 以及5)评估疫苗试验在这方面的可行性 人口。WITS II是目前资助的一项研究的继续 (WITS I)它将利用核心WITS I协议以及 根据当前知识状态进行适当的修改以 收集流行病学、医学和实验室数据。一位敬业的 标本库将提供独特的样品用于评估 创新的早期诊断技术以及利用 在回答关键研究方面的最新实验室技术 问题。

The Women and Infants Transmission Study (WITS-II) will enroll HIV-infected pregnant women and their infants into a multicenter, epidemiologic cohort study whose objectives are to answer critical questions relevant to HIV disease during pregnancy, and maternal-infant transmission. In addition, research issues relevant to implementation of therapeutic intervention in this population will be addressed. The specific aims of WITS II are 1) to assess the effects of pregnancy on maternal HIV progression 2) to determine maternal co-factors related to vertical transmission 3) to evaluate techniques for early diagnosis of infected infants 4) to describe the natural history of HIV disease in infected infants and 5) to assess the feasibility of vaccine trials in this population. WITS II is a continuation of a currently funded study (WITS I). It will utilize core WITS I protocols along with modifications appropriate to the current state of knowledge to gather epidemiologic, medical, and laboratory data. A dedicated specimen repository will provide unique samples for evaluation of innovative early diagnostic techniques as well as for utilization of state of the art lab techniques in answering key research questions.