MAGNESIUM METABOLISM IN HUMAN AND BIOLOGICAL SYSTEMS

已发现女性体内存在镁代谢异常。 患有经前综合症(PMS)。我们评估了血浆和红血球 细胞和单个核血细胞的镁浓度 26例经前综合征妇女和19例对照妇女的月经周期。数据是 使用具有重复测量的变种分析和 斯皮尔曼等级关联。结果显示， 红细胞和单个核细胞中镁的浓度 与对照组相比，在每个采样时间患有经前综合症的妇女。这些 缺陷并不局限于黄体期，而是存在的。 在整个月经周期中。 此外，我们评估了血液镁参数和血浆 一项双盲安慰剂对照研究中的钙镁比 在多动症男孩中使用哌醋甲酯和右旋安非他明。电浆 服用右旋安非他明3周后镁显著升高。 钙镁比在3周后显著降低。 将两种药物与基线或安慰剂进行比较。这一数字的下降 钙镁比可能与我们对侧面的理解有关 与兴奋剂使用有关的影响和“治疗抵抗”。

Abnormalities in magnesium metabolism have been identified in women with the Premenstrual Syndrome (PMS). We evaluated plasma, red blood cell and mononuclear blood cell magnesium concentration across the menstrual cycle in 26 women with PMS and 19 control women. Data were analyzed using analysis of variants with repeated measures and Spearman rank correlations. The results showed a significant decrease in red blood cell and mononuclear blood cell magnesium concentrations for women with PMS at each sampling time compared to controls. These deficits were not confined to the luteal phase but were present throughout the menstrual cycle. Further, we evaluated blood magnesium parameters and the plasma calcium to magnesium ratio in a double-blind placebo-controlled study of methylphenidate and dextroamphetamine in hyperactive boys. Plasma magnesium was significantly higher after 3 weeks of dextroamphetamine and the calcium-magnesium ratio was significantly lower after 3 weeks of either drug compared to baseline or placebo. The decrease in the calcium-magnesium ratio may be relevant to our understanding of side effects and "treatment resistance" associated with stimulant use.