NEUROBIOLOGY OF OPIOID DEPENDENCE

阿片类药物依赖性的神经生物学

• 批准号: 2116098
• 负责人: Marc I Rosen
• 金额: $ 10.5万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2116098
• 关键词: aminoacid inhibitor; blood chemistry; calcium channel blockers; clinical trials; clonidine; detoxification; drug abuse chemotherapy; drug abuse education; drug screening /evaluation; drug withdrawal; excitatory aminoacid; human subject; human therapy evaluation; naloxone; neurobiology; neuropharmacology; neurotransmitter metabolism; opiate alkaloid; questionnaires

This application is to study excitatory amino acid inputs and calcium- linked neurotransmitter release during opiate withdrawal. The proposed program of research will examine: 1) spontaneous opiate withdrawal in clinical opiate detoxification studies, and 2) naloxone-precipitated opiate withdrawal in a repeated challenge paradigm. The excitatory amino acid contribution to opiate withdrawal will be studied initially with dextromethorphan, a widely used non-opioid antitussive which inhibits excitatory amino acid neurotransmission in pre-clinical studies, and has shown pilot efficacy for treatment of opiate withdrawal. Based on pre- clinical and pilot human studies, the proposed research will determine the anti-withdrawal efficacy of nimodipine, a centrally-acting calcium channel blocker.

这个应用程序是研究兴奋性氨基酸输入和钙- 与阿片类药物戒断时神经递质的释放有关 拟议 研究计划将检查：1）自发阿片类药物戒断， 临床阿片解毒研究，和2）纳洛酮沉淀 阿片类药物戒断在一个重复的挑战范例。 兴奋性氨基酸 酸对阿片类药物戒断的贡献将首先研究， 美沙芬，一种广泛使用的非阿片类镇咳药， 兴奋性氨基酸神经传递的临床前研究， 显示了治疗阿片类药物戒断的初步疗效。 根据预- 临床和试点人体研究，拟议的研究将确定 尼莫地平抗戒断作用 通道阻断器。