EFFECTS OF RISING SINGLE ORAL DOSES OF L-706,000 ON CORON. ART. DISEASE

增加单次口服剂量的 L-706,000 对 CORON 的影响。

• 批准号: 3761436
• 负责人: STEPHEN F SCHAAL
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3761436
• 关键词: antiarrhythmic agent; cardiovascular disorder chemotherapy; coronary artery; coronary disorder; dosage; drug adverse effect; drug screening /evaluation; heart rate; human subject; human therapy evaluation; oral administration

This randomized, double-blind, placebo-controlled, multicenter study will test the following hypotheses: 1) oral administration of L-706,000 will produce a dose-related prolongation of the QTC interval (QT interval corrected for heart rate), and 2) oral administration of L-706,000 will be safe and well-tolerated in patients with coronary artery disease.

这项随机、双盲、安慰剂对照的多中心研究将 检验以下假设：1)口服L-706,000将 产生与剂量相关的QTC间期延长(QT间期 校正心率)，以及2)口服L-706,000威尔 对冠心病患者安全且耐受性良好。