SCOR--LUNG BIOLOGY AND DISEASES IN INFANTS AND CHILDREN

SCOR--婴儿和儿童的肺生物学和疾病

• 批准号: 2222954
• 负责人: PHILIP M FARRELL
• 金额: $ 62.15万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-30 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2222954
• 关键词: bronchopulmonary dysplasia; child (0-11); human subject; premature infant human; respiratory distress syndrome of newborn

The UW-Madison Specialized Center of Research on "Lung Biology and Disease in Infants and Children" will be devoted to elucidation of the pathobiology of bronchopulmonary dysplasia (BPD), particularly the delineation of cellular and biochemical mechanisms potentially important in either the pathogenesis of neonatal lung injury or the repair processes that facilitate recovery from chronic respiratory insufficiency of infants. This mission will be addressed in a multidisciplinary research program featuring a combination of interrelated basic and clinical investigations designed to expedite the development and application of new knowledge that might improve our understanding and treatment of bronchopulmonary dysplasia. There will be four research projects entitled: 1. Assessment of the role of oxyradicals in the pathogenesis of BPD. 2. Retinol function in the pathogenesis and repair of BPD. 3. Calcium-dependent phospholipid-binding proteins as related to lung development, RDS, and BPD. 4. Effect of hyperoxia on alveolar type II cell proliferation and differentiation during neonatal lung growth. These investigation, will be facilitated by three core units providing: a) administrative services; b) biostatistics/computing resources and assistance; and c) research coordinating support.

威斯康星大学麦迪逊分校肺生物学和疾病研究专业中心 在婴儿和儿童”将致力于阐明的病理生物学 支气管肺发育不良（BPD），特别是描绘 细胞和生物化学机制， 新生儿肺损伤的发病机制或修复过程， 促进婴儿慢性呼吸功能不全的恢复。 这一使命将在一个多学科研究计划中得到解决 以相互关联的基础和临床研究相结合为特色 旨在加快新知识的开发和应用， 可能会提高我们对支气管肺炎的认识和治疗 发育不良 将有四个研究项目，题为： 1. 评估氧自由基在BPD发病机制中的作用。 2. 视黄醇在BPD发病机制和修复中的作用。 3. 与肺相关的钙依赖性磷脂结合蛋白 发展、RDS和BPD。 4. 高氧对肺泡II型细胞增殖和分化的影响 新生儿肺生长过程中的分化。 这些调查将由三个核心单位提供便利： 行政服务; B）生物统计/计算资源，以及 （三）研究协调支持。