SCOR IN CORONARY AND VASCULAR DISEASES

冠状动脉和血管疾病中的 SCOR

• 批准号: 2215040
• 负责人: Lewis C Becker
• 金额: $ 197.6万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2215040
• 关键词: myocardial infarction; myocardial ischemia /hypoxia; reperfusion

This is a multidisciplinary proposal to explore the fundamental pathophysiology and biochemistry of ischemic and infarcted myocardium and to implement knowledge of the pathophysiology of this disease into programs to: (1) identify those at risk of serious ischemic events and (2) examine means for improving the management of those patient manifesting ischemic heart disease. Studies of the metabolism of ischemic myocardium will utilize nuclear magnetic resonance to identify rapid changes in energy state. The importance of shape changes, relaxation characteristics of myocardium and ischemic and scarred myocardium as determinants of left ventricular function will be examined in animal models and man. The role of prostaglandins in ischemia and in the mechanism of action of cardiac active drugs will be explored. We will attempt to identify the anatomic predictors of sudden cardiac death invasively and non-invasively as well as explore risk factor profile in relationship to anatomic coronary lesions and prognosis. We will explore the therapeutic potential of a new automatic implantable defibrillator device in man. Randomized clinical intervention trials will include: (1) nitroglycerin plus propranolol in low risk patients with acute infarction (vs. placebo); (2) intraaortic balloon pumping and nitroglycerin in high risk patients with acute infarction (vs. routine therapy); (3) new vs. conventional cardiopulmonary resuscitative techniques; (4) a slow channel blocker (vs. placebo) in patients with unstable angina pectoris; (5) a membrane active anti-arrhythmic agent vs. placebo in survivors of acute infarcts assessed to be at high risk of subsequent sudden death and (6) use of perioperative agents for decreasing complications of coronary bypass surgery. Core support laboratories include: Pathology, Nuclear Cardiology, Echocardiography and Pharmacology.

这是一个多学科的建议，以探索基本病理生理学

项目成果

Correction for patient and organ movement in SPECT: application to exercise thallium-201 cardiac imaging.

• 发表时间: 1988-04
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: W. Geckle;Terry L. Frank;Jonathan M. Links;Lewis C. Becker

Regulation of myocardial glycogenolysis during post-ischemic reperfusion.

缺血后再灌注期间心肌糖原分解的调节。

• DOI: 10.1016/0022-2828(91)90192-o
• 发表时间: 1991
• 期刊: Journal of molecular and cellular cardiology
• 影响因子: 5
• 作者: Kalil-Filho,R;Gerstenblith,G;Hansford,RG;Chacko,VP;Vandegaer,K;Weiss,RG
• 通讯作者: Weiss,RG

Fatty acid regulation of glucose metabolism in the intact beating rat heart assessed by carbon-13 NMR spectroscopy: the critical role of pyruvate dehydrogenase.

通过碳 13 NMR 光谱评估完整跳动大鼠心脏中葡萄糖代谢的脂肪酸调节：丙酮酸脱氢酶的关键作用。

• DOI: 10.1016/0022-2828(89)90787-6
• 发表时间: 1989
• 期刊: Journal of molecular and cellular cardiology
• 影响因子: 5
• 作者: Weiss,RG;Chacko,VP;Gerstenblith,G
• 通讯作者: Gerstenblith,G

Circulatory assistance by intrathoracic pressure variations: optimization and mechanisms studied by a mathematical model in relation to experimental data.

胸腔内压力变化的循环辅助：通过与实验数据相关的数学模型研究的优化和机制。

• DOI: 10.1161/01.res.64.4.703
• 发表时间: 1989
• 期刊: Circulation research
• 影响因子: 20.1
• 作者: Beyar,R;Halperin,HR;Tsitlik,JE;Guerci,AD;Kass,D;Weisfeldt,ML;Chandra,NC
• 通讯作者: Chandra,NC

Limitations of regional myocardial thallium clearance for identification of disease in individual coronary arteries.

局部心肌铊清除率在识别个体冠状动脉疾病方面的局限性。

• DOI: 10.1016/0735-1097(89)90387-2
• 发表时间: 1989
• 期刊: Journal of the American College of Cardiology
• 影响因子: 24
• 作者: Becker,LC;RogersJr,WJ;Links,JM;Corn,C
• 通讯作者: Corn,C