European Network on the Supramolecular Chemistry of Carbohydrates

欧洲碳水化合物超分子化学网络

• 批准号: EP/Y028058/1
• 负责人: Anthony Davis
• 金额: $ 33.22万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY028058%2F1
• 关键词: European; Network; Supramolecular; Chemistry; Carbohydrates

Carbohydrates are nature's most abundant and versatile molecules and are involved in several diseases (e.g. diabetes, infection, and cancer metastasis) and other regular processes (e.g. fertilization, immune surveillance and inflammatory responses). Understanding, monitoring and intervening in these processes could be exploited in medicinal therapies, glycobiology, and biomedical research in general. Such applications are predicated on the availability of carbohydrate binding molecules (CBMs) that can selectively and supramolecularly (noncovalently) bind a plethora of carbohydrate molecules ranging from simple monosaccharides to complex oligosaccharides and glycoconjugates. Technologies that can be developed based on CBMs include: the separation and isolation of carbohydrate containing molecules; making carbohydrate sensing and detection devices; enabling selective chemistry on (unprotected) carbohydrates; and a range of bio-functional applications. While the expertise to design, synthesize, study and exploit CBMs is mostly European, the research groups active in this emerging field work independent from each other. With this doctoral network grant, we aim to unite this expertise in the 'European Network for the Supramolecular Chemistry of Carbohydrates' (ENSCC). With most of the world's leading minds on the topic and three companies that are spearheading technologies in the field, our ENSCC will be a European powerhouse that will lead the academic field globally for years to come. This will be achieved by sharing expertise, key-infrastructure, molecular building blocks, and -most importantly- by together training the ten PhDs that this doctoral network grant will fund. This training by a unique network of world-leaders, experts in the field and companies with an interest in CBMs will perfectly position our PhD students to further develop the field by continuing their career in academia and/or industry.

碳水化合物是自然界中最丰富和最通用的分子，并参与多种疾病（例如糖尿病，感染和癌症转移）和其他常规过程（例如受精，免疫监视和炎症反应）。理解，监测和干预这些过程可以在药物治疗，糖生物学和生物医学研究中得到利用。这些应用是基于碳水化合物结合分子（CBM）的可用性，所述碳水化合物结合分子可以选择性地和超分子地（非共价地）结合从简单单糖到复杂寡糖和糖缀合物的大量碳水化合物分子。可以基于CBM开发的技术包括：分离和隔离含碳水化合物的分子;制造碳水化合物传感和检测设备;实现对（未受保护的）碳水化合物的选择性化学;以及一系列生物功能应用。虽然设计、综合、研究和利用建立信任措施的专门知识主要来自欧洲，但活跃在这一新兴领域的研究小组相互独立。有了这个博士网络补助金，我们的目标是在“欧洲网络的碳水化合物的超分子化学”（ENSCC）团结这方面的专业知识。随着世界上大多数关于这个话题的领先思想和三家在该领域领先技术的公司的加入，我们的ENSCC将成为一个欧洲强国，在未来几年内引领全球学术领域。这将通过分享专业知识，关键基础设施，分子构建模块来实现，最重要的是，通过共同培训该博士网络资助的10名博士。由世界领先者，该领域专家和对CBM感兴趣的公司组成的独特网络的培训将完美地定位我们的博士生，通过继续他们在学术界和/或工业界的职业生涯来进一步发展该领域。