Synthesis and Applications of Nanoporous Steroidal Crystals

纳米孔甾体晶体的合成及应用

• 批准号: EP/E021581/1
• 负责人: Anthony Davis
• 金额: $ 39.91万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE021581%2F1
• 关键词: Synthesis; Applications; Nanoporous; Steroidal; Crystals

The properties of materials depend partly on those of their component molecules, but also on the way the molecules arrange themselves relative to each other. The design of molecules which will self-organise in specific, predictable ways is termed crystal engineering , and is a major challenge for current science. One arrangement of special value is a nanoporous assembly, in which the molecules pack together in such a way as to leave channels running through the material. The channels can then be filled with other molecules, to give hybrids with novel properties. Alternatively, the materials can be used as molecular sieves , allowing some molecules to pass through but blocking others. Although useful, nanoporous structures are intrinsically difficult to achieve; generally, nature prefers to occupy space when forming a crystal. We have recently discovered a family of molecules which not only have this rare property, but for which the channels are also exceptionally wide. Unusually, they are big enough to accept a wide range of guests including, for example, molecules which absorb light (and are therefore coloured). The members of the family all crystallise in the same way, so that their structures should be predictable, allowing tuning of properties.We believe this discovery can be exploited to create new materials with a variety of useful properties. Firstly we need to establish the size of the family - how much can we change the structure and still keep the nanoporous arrangement? Secondly we need to study the materials' abilities to absorb, or form around, other molecules. This work may show that we can achieve difficult separations (including chiral separations) by careful tailoring of channel properties. Other objectives include: (a) Making the materials stronger by creating bonds between the molecules. (b) Arranging dye molecules in the channels, such that they can work together to moderate light waves. (c) Forming mixed crystals, in which the shapes of the channel walls can be controlled by the presence of guests. (d) Depositing metals in the channels, creating nanoparticles or nanowires . If successful the research could have applications in chemical processing (separations and catalysis), optical technology and nanotechnology.

材料的性质部分取决于其组成分子的性质，但也取决于分子之间的相对排列方式。以特定的、可预测的方式自组织的分子的设计被称为晶体工程，是当前科学的一个重大挑战。一种具有特殊价值的排列是纳米多孔组装，其中分子以这样一种方式聚集在一起，从而留下贯穿材料的通道。然后可以用其他分子填充通道，以获得具有新特性的混合物。或者，这些材料可以用作分子筛，允许一些分子通过，但阻止其他分子。虽然有用，但纳米多孔结构本质上难以实现;通常，当形成晶体时，自然倾向于占据空间。我们最近发现了一类分子，它们不仅具有这种罕见的性质，而且通道也非常宽。不寻常的是，它们大到足以接受各种各样的客人，包括例如吸收光的分子（因此是彩色的）。该家族的成员都以相同的方式结晶，因此它们的结构应该是可预测的，允许调整性能。我们相信这一发现可以用来创造具有各种有用性能的新材料。首先，我们需要确定家族的规模-我们可以改变多少结构，仍然保持纳米孔排列？其次，我们需要研究材料吸收或形成其他分子的能力。这项工作可能表明，我们可以实现困难的分离（包括手性分离）通过仔细剪裁的通道特性。其他目标包括：（a）通过在分子之间建立键合使材料更坚固。(b)在通道中排列染料分子，这样它们就可以一起工作来缓和光波。(c)形成混合晶体，其中通道壁的形状可以通过客人的存在来控制。(d)在通道中沉积金属，形成纳米颗粒或纳米线。如果成功的话，这项研究可以应用于化学加工（分离和催化），光学技术和纳米技术。

项目成果

Cholanamide components for organic alloys; expanding the scope of nanoporous steroidal ureas.

用于有机合金的胆酰胺成分；

• DOI: 10.1039/c4cc01256a
• 发表时间: 2014
• 期刊: Chemical communications (Cambridge, England)
• 作者: Travaglini L

Tunable porous organic crystals: structural scope and adsorption properties of nanoporous steroidal ureas.

• DOI: 10.1021/ja405701u
• 发表时间: 2013-11-13
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Natarajan R;Bridgland L;Sirikulkajorn A;Lee JH;Haddow MF;Magro G;Ali B;Narayanan S;Strickland P;Charmant JP;Orpen AG;McKeown NB;Bezzu CG;Davis AP
• 通讯作者: Davis AP

A steroid-based receptor for unprotected amino acids: the enantioselective recognition of l-tryptophan

未受保护氨基酸的类固醇受体：L-色氨酸的对映选择性识别

• DOI: 10.1016/j.tet.2010.06.069
• 发表时间: 2010
• 期刊: Tetrahedron
• 影响因子: 2.1
• 作者: Sirikulkajorn A