PRIMITIVE POPULATIONS--CHILD DEVELOPMENT,BEHAVIOR,AND DISEASE PATTERNS

原始人群——儿童发育、行为和疾病模式

• 批准号: 3760201
• 负责人: CARLETON GAJDUSEK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3760201
• 关键词: Alzheimer's disease; Bunyaviridae; HIV infections; Retroviridae; aging; amyotrophic lateral sclerosis; child (0-11); child physical development; culture; environmental toxicology; evolution; human subject; human tissue; interview; latent virus infection; mental disorders; nervous system disorder; nutrition; nutrition related tag; sex behavior; spongiform encephalopathy

Studies of human biology of vanishing primitive societies focus on neurologic development and learning patterns in diverse cultural experiments in the human condition found in such isolated groups. Opportunistic investigation of problems phrased by man in isolation is the basis of approach from which most of our studies evolved: kuru-CJD GSS-FFI, HIV (AIDS), HTLV-I slow virus infections of the CNS, aging and Alzheimer-s, VE, ALS-PD, mental disease, toxic neuropathies. Techniques of molecular genetics, biochemistry, immunology, virology, and field epidemiologic, clinical linguistic and behavioral studies in cultural isolates and genetic and-or geographically isolated primitive bands yield more easily interpretable data than in cosmopolitan societies. Data and specimens from expeditions to Micronesia, Melanesia, Polynesia, South America, Asia and Africa were valuable in recent HIV (AIDS), HTLV-I hantavirus, JCV of PML and herpesvirus, CMV and EBV studies. Studies on nutrition, reproduction, fertility, age of puberty and aging, genetic distance and pleomorphisms, unusual and odd higher cortical functions in language learning, cognitive styles, computation (calculation without words or numbers) and culturally modified sexual behavior elucidate alternative forms of neurologic functioning for man which we cannot investigate once the natural cultural experiments in primitive human isolates are amalgamated into the cosmopolitan community of man. Foci of high incidence of kuru, ALS-PD, HTLV-I myelopathy, epilepsy, familial parkinsonism, Viliuisk encephalopathy, other CNS degenerations, hysterical disorders, schizophrenia, bi-polar psychoses, neoplasms, goiter, cretinism, rheumatoid diseases, diabetes, asthma, chronic lung disease, malaria, filariasis, leprosy, cysticercosis, and other infections in these isolated groups have yielded widely significant discoveries. HFRS caused by hantaviruses in Asia, USSR, Europe and newly recognized hantaviruses in the U.S. are studied. Human evolution and adaptability to high altitude, various climes, variable food supply, mineral deficiencies, toxic exposures and responses to severe diseases or social psychologic stress are studied in appropriate populations. Thus, HTLV-1 and HIV retroviruses as causes of CNS diseases in man were first found and are best studied in isolated or socially segregated groups: high incidence TSP focus in Tuamaco, Colombia; drug-using mothers in Newark, New Jersey; epidemic neuropathy in Cuba. We new have a proto-Melanesian variant of HTLV-I in New Guinea and Solomon Islands, of an archaic origin, not associated with monkeys at least for millennia.

对正在消失的原始社会的人类生物学研究集中在 不同文化背景下的神经发育和学习模式 在这些孤立的群体中发现的人类条件的实验。 对人孤立地提出的问题进行实证研究， 我们大多数研究的基础：库鲁-克雅氏病 GSS-FFI、HIV（AIDS）、HTLV-I减缓CNS的病毒感染、衰老和 老年痴呆症、VE、ALS-PD、精神疾病、中毒性神经病变。技术 分子遗传学、生物化学、免疫学、病毒学和 流行病学、临床语言学和行为学研究 分离物和遗传和/或地理隔离的原始带产生 更容易解释的数据比在国际社会。数据和 标本从探险密克罗尼西亚，美拉尼西亚，波利尼西亚，南 美洲、亚洲和非洲在最近的艾滋病毒（艾滋病）、HTLV-I 汉坦病毒、PML和疱疹病毒的JCV、CMV和EBV研究。研究 营养、生殖、生育、青春期和衰老年龄、遗传 距离和多形性，不寻常的和奇怪的高级皮质功能， 语言学习，认知风格，计算（无计算） 文字或数字）和文化上改变的性行为 人类神经功能的替代形式， 考察一次原始人类的自然文化实验 分离物融合到人类的大都市社区中。 库鲁病、ALS-PD、HTLV-I型脊髓病、癫痫、家族性 帕金森综合征、维留伊斯克脑病、其他CNS变性， 癔病、精神分裂症、双相精神病、肿瘤、 甲状腺肿、克汀病、类风湿性疾病、糖尿病、哮喘、慢性肺 疾病，疟疾，丝虫病，麻风病，囊虫病，和其他 这些孤立群体中的感染产生了广泛的显着影响， 发现。汉坦病毒引起的肾综合征出血热在亚洲、苏联、欧洲和新 在美国被认可的汉坦病毒进行了研究。人类进化和 适应高海拔，各种气候，多变的食物供应， 矿物质缺乏、有毒物质暴露和对严重疾病的反应 或社会心理压力在适当的人群中进行研究。 因此，HTLV-1和HIV逆转录病毒作为人类中枢神经系统疾病的原因， 最早发现和最好的研究是在孤立的或社会隔离的 群体：哥伦比亚Tuamaco的TSP高发区;吸毒母亲 在新泽西的纽瓦克;在古巴的流行性神经病。我们有一个新的 新几内亚和所罗门群岛的HTLV-I的原美拉尼西亚变体， 这是一个古老的起源，至少几千年来与猴子无关。