Simultaneous Eye-safe Spectroscopy and Fundus Imaging Technology for Point-of-Care Detection of Traumatic Brain Injury

用于即时检测脑外伤的同时人眼安全光谱和眼底成像技术

• 批准号: EP/Y030206/1
• 负责人: Pola Goldberg Oppenheimer
• 金额: $ 212.28万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY030206%2F1
• 关键词: Simultaneous; Eye; safe; Spectroscopy; Fundus

Millions of people world-wide die from late diagnosis every year. In particular, in emergency care practice, life- critical decisions must be made rapidly, influencing patients' prognosis and the efficacy of treatment. There is a critical window for diagnosis of many acute diseases such as, traumatic brain injury (TBI) - a leading cause of morbidity and mortality worldwide. TBI has become a major challenge of the 21st century and by 2028, the WHO estimates that neuro-trauma will become the leading cause of death worldwide. While life-changing decisions must be made rapidly, it is notoriously hard to diagnose at the point-of-care, resulting in incorrect patient management and the chances of an individual suffering cognitive or physical impairment are massively increased. Current diagnostic technologies are woefully inadequate either requiring large equipment, long- waiting times, invasive or not sensitive and timely enough. There is an urgent need for new technologies to achieve timely intervention through rapid and accurate TBI diagnostics at the point-of-care.This research will open new horizons in medical devices by exploring how cutting-edge Engineering methods can enable a platform technology that will lead to next generation of applications in miniaturised sensors, monitoring and pharmaceuticals. Underpinning the topic is the development of pioneering portable technology for instantaneous detection of TBI-specific molecular changes, via simultaneous Raman spectroscopy and fundus imaging, to safely measure proxies of cerebral injury via the neuroretina and optic nerve, thus uniquely providing a window into brain biochemistry. Such disruptive technology will enable the low-cost manufacture of a handheld device for early diagnosis of acute injury, whether at the pitch side in contact sports, or the roadside following traffic accidents, will not only inform correct clinical pathways but also mitigate against death and disability from this devastating disease.

全世界每年有数以百万计的人死于诊断延误。特别是，在急救实践中，必须迅速做出关键生命的决定，影响患者的预后和治疗效果。许多急性疾病的诊断都有一个关键的窗口，例如创伤性脑损伤(TBI)--这是全球发病率和死亡率的主要原因。脑外伤已成为21世纪的主要挑战，世界卫生组织估计，到2028年，神经创伤将成为全球主要的死亡原因。虽然必须迅速做出改变人生的决定，但众所周知，在护理地点很难诊断，导致不正确的患者管理，个人遭受认知或身体损害的可能性大大增加。目前的诊断技术严重不足，要么需要大型设备，等待时间长，要么是侵入性的，要么不够灵敏和及时。迫切需要新技术在护理点通过快速和准确的脑损伤诊断实现及时干预。这项研究将通过探索尖端工程方法如何使平台技术能够在微型传感器、监测和制药领域实现下一代应用，从而打开医疗设备的新视野。这一主题的基础是开发开创性的便携式技术，通过同步拉曼光谱和眼底成像来瞬时检测脑损伤特定的分子变化，以安全地测量经由神经视网膜和视神经的脑损伤指标，从而独特地提供了解脑生物化学的窗口。这种颠覆性技术将使低成本制造用于急性损伤早期诊断的手持设备，无论是在接触性运动的场地侧，还是在交通事故后的路边，不仅将为正确的临床路径提供信息，还将减少这种毁灭性疾病的死亡和残疾。