Simultaneous Eye-safe Spectroscopy and Fundus Imaging Technology for Point-of-Care Detection of Traumatic Brain Injury

用于即时检测脑外伤的同时人眼安全光谱和眼底成像技术

• 批准号: EP/Y030206/1
• 负责人: Pola Goldberg Oppenheimer
• 金额: $ 212.28万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY030206%2F1
• 关键词: Simultaneous; Eye; safe; Spectroscopy; Fundus

Millions of people world-wide die from late diagnosis every year. In particular, in emergency care practice, life- critical decisions must be made rapidly, influencing patients' prognosis and the efficacy of treatment. There is a critical window for diagnosis of many acute diseases such as, traumatic brain injury (TBI) - a leading cause of morbidity and mortality worldwide. TBI has become a major challenge of the 21st century and by 2028, the WHO estimates that neuro-trauma will become the leading cause of death worldwide. While life-changing decisions must be made rapidly, it is notoriously hard to diagnose at the point-of-care, resulting in incorrect patient management and the chances of an individual suffering cognitive or physical impairment are massively increased. Current diagnostic technologies are woefully inadequate either requiring large equipment, long- waiting times, invasive or not sensitive and timely enough. There is an urgent need for new technologies to achieve timely intervention through rapid and accurate TBI diagnostics at the point-of-care.This research will open new horizons in medical devices by exploring how cutting-edge Engineering methods can enable a platform technology that will lead to next generation of applications in miniaturised sensors, monitoring and pharmaceuticals. Underpinning the topic is the development of pioneering portable technology for instantaneous detection of TBI-specific molecular changes, via simultaneous Raman spectroscopy and fundus imaging, to safely measure proxies of cerebral injury via the neuroretina and optic nerve, thus uniquely providing a window into brain biochemistry. Such disruptive technology will enable the low-cost manufacture of a handheld device for early diagnosis of acute injury, whether at the pitch side in contact sports, or the roadside following traffic accidents, will not only inform correct clinical pathways but also mitigate against death and disability from this devastating disease.

全世界每年有数百万人死于晚期诊断。特别是，在急诊护理实践中，必须迅速做出生命关键的决定，这影响患者的预后和治疗效果。对于许多急性疾病的诊断有一个关键的窗口，例如创伤性脑损伤（TBI）-世界范围内发病率和死亡率的主要原因。TBI已成为21世纪世纪的主要挑战，到2028年，WHO估计神经创伤将成为全球死亡的主要原因。虽然必须迅速做出改变生活的决定，但众所周知，在护理点很难诊断，导致不正确的患者管理，并且个人遭受认知或身体损伤的机会大大增加。目前的诊断技术严重不足，要么需要大型设备，等待时间长，侵入性强，要么不够敏感和及时。目前迫切需要新技术，通过快速准确的TBI诊断在床旁实现及时干预。这项研究将通过探索尖端工程方法如何实现平台技术，从而打开医疗设备的新视野，该平台技术将导致下一代传感器，监测和制药的应用。该主题的基础是开发了一种先进的便携式技术，用于通过同时进行拉曼光谱和眼底成像来即时检测TBI特异性分子变化，以通过神经视网膜和视神经安全地测量脑损伤的代理，从而独特地提供了一个了解脑生物化学的窗口。这种颠覆性的技术将使低成本制造的手持设备的早期诊断急性损伤，无论是在球场边的接触性运动，或路边的交通事故后，不仅会通知正确的临床路径，而且还减少死亡和残疾从这种毁灭性的疾病。