FACTORS CONTROLLING TOLERANCE TO APOMORPHINE TREATMENT IN PARKINSON'S DISEASE

控制帕金森病阿扑吗啡治疗耐受性的因素

• 批准号: 3764473
• 负责人: STEPHEN T GANCHER
• 金额: --
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3764473
• 关键词: Parkinson's disease; antiparkinson drugs; apomorphine; drug adverse effect; drug screening /evaluation; drug tolerance; human subject; human therapy evaluation; neuromuscular disorder chemotherapy; pharmacokinetics

The aim of these studies is to design better therapies for parkinsonism and to investigate the practicality of apomorphine in the treatment of severe fluctuations. We believe that in the parkinsonian patient with fluctuations, a decrease in the sensitivity to dopaminergic stimulation occurs within several hours of treatment, but that this loss of sensitivity is reversed after a several hour period.

这些研究的目的是为帕金森病设计更好的治疗方法