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FACTORS CONTROLLING TOLERANCE TO APOMORPHINE TREATMENT IN PARKINSON'S DISEASE

FACTORS CONTROLLING TOLERANCE TO APOMORPHINE TREATMENT IN PARKINSON'S DISEASE
控制帕金森病阿扑吗啡治疗耐受性的因素
批准号：
3764473
负责人：
STEPHEN T GANCHER
金额：
$0.0万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3764473
关键词：
Parkinson's disease antiparkinson drugs apomorphine drug adverse effect drug screening /evaluation drug tolerance human subject human therapy evaluation neuromuscular disorder chemotherapy pharmacokinetics

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中文摘要
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英文摘要
The aim of these studies is to design better therapies for parkinsonism and to investigate the practicality of apomorphine in the treatment of severe fluctuations. We believe that in the parkinsonian patient with fluctuations, a decrease in the sensitivity to dopaminergic stimulation occurs within several hours of treatment, but that this loss of sensitivity is reversed after a several hour period.
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SUBLINGUAL APOMORPHINE IN PARKINSON'S DISEASE--TOLERABILITY AND EFFICACY
SUBLINGUAL APOMORPHINE IN PARKINSON'S DISEASE--TOLERABILITY AND EFFICACY
SUBLINGUAL APOMORPHINE IN PARKINSON'S DISEASE--TOLERABILITY AND EFFICACY
ALTERATIONS IN DOPAMINERGIC RESPONSE IN PARKINSONISM