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MONITORING PARKINSONISM IN PATIENTS WITH COMPLEX PATTERNS OF RESPONSE

MONITORING PARKINSONISM IN PATIENTS WITH COMPLEX PATTERNS OF RESPONSE
监测具有复杂反应模式的帕金森病患者
批准号：
3786542
负责人：
STEPHEN T GANCHER
金额：
$0.0万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3786542
关键词：
Parkinson's disease antiparkinson drugs dihydroxyphenylalanine human subject human therapy evaluation nervous system disorder chemotherapy neurologic manifestations patient monitoring device pharmacokinetics

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中文摘要
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英文摘要
Parkinsonian patients treated chronically with levodopa may develop complex fluctuations of neurological symptoms. We will monitor patients' neurological signs and plasma levodopa hourly throughout the waking hours for two days to: 1. Determine if establishing the magnitude and pattern of fluctuating symptoms and signs leads to improved control and would be a cost effective service. 2. Explore unusual patterns of response for other clues to the pharmacokinetic and pharmacodynamic properties of levodopa.
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