Holographic Integrated Photonics Platform for the Optical Analysis of Biological Samples

用于生物样品光学分析的全息集成光子学平台

• 批准号: EP/Y036182/1
• 负责人: Andrea Di Falco
• 金额: $ 16.19万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY036182%2F1
• 关键词: Holographic; Integrated; Photonics; Platform; Optical

We propose to develop an integrated photonic platform based on holographic metasurfaces (HIPPO) for the high-throughputimaging of biological specimens in microfluidic environments. The integrated platform combines high spatial resolution and largefield of view acquisition with the throughput requirements of modern screening techniques. Current solutions rely upon complexillumination systems and bulky imaging setups to increase the spatial spectrum range and reduce the background fluorescence.The goal of this project is to move the complexity to a portable optofluidic chip and pave the way for high-throughput assays in everybiology lab, turning high-throughput and high-resolution microscopy into an instrument for biologists, rather than for biophysicists.

我们提出了一种基于全息超表面（HIPPO）的集成光子平台，用于微流控环境下生物标本的高通量成像。该综合平台将高空间分辨率和大视场采集与现代筛选技术的吞吐量要求相结合。目前的解决方案依赖于复杂的照明系统和庞大的成像装置来增加空间光谱范围和减少背景荧光。该项目的目标是将复杂性转移到便携式光流芯片上，并为每个生物实验室的高通量分析铺平道路，将高通量和高分辨率显微镜变成生物学家的工具，而不是生物物理学家。